351003-62-8

Basic information

• Product Name: 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE
• Synonyms: SALOR-INT L301078-1EA;4-BROMO-2-(TRIFLUOROMETHYL)BENZENESULPHONAMIDE;4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE;4-BROMO-2-(TRIFLLUOROMETHYL)BENZENESULPHONAMIDE;4-Bromo-6-trifluoromethylbenzenesulfonamide;4-Bromo-6-trifluoromethylbenzene;5-Bromo-2-sulphamoylbenzotrifluoride, 2-(Aminosulphonyl)-5-bromobenzotrifluoride
• CAS NO: 351003-62-8
• Molecular Formula: C₇H₅BrF₃NO₂S
• Molecular Weight: 304.08
• Mol File: 351003-62-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 157-158°C
• Boiling Point: 346.6 °C at 760 mmHg
• Flash Point: 163.4 °C
• Appearance: /
• Density: 1.809 g/cm³
• Vapor Pressure: 5.71E-05mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE(351003-62-8)
• EPA Substance Registry System: 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE(351003-62-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 351003-62-8(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-(trifluoromethyl)benzene sulfonamide is a chemical compound with the molecular formula C7H6BrF3NO2S. It is a white solid with a molecular weight of 295.09 g/mol. 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE is used as a pharmaceutical intermediate and is a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis and chemical research. It is important to handle this compound with care as it can cause skin and eye irritation, and it should be stored in a cool, dry place away from direct sunlight and heat sources.

InChI:InChI=1/C7H5BrF3NO2S/c8-4-1-2-6(15(12,13)14)5(3-4)7(9,10)11/h1-3H,(H2,12,13,14)

Upstream product

• 176225-10-8 4-bromo-2-(trifluoromethyl)benzene-1-sulfonyl chloride 

Downstream Products

• 1034925-43-3 4-(2,4-dichloro-phenylamino)-2-trifluoromethyl-benzenesulfonamide 

Relevant articles and documents

PHOSPHODIESTERASE INHIBITORS AND USE

The invention provides compounds that may inhibits to ENPP1, and are accordingly useful for treatment disorders related to ENPP1. The invention further provides pharmaceutical compositions containing these compounds and methods of using these compounds to treat or prevent disorders related to ENPP1.

SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS

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Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

Virtual screening against a pCDK2/cyclin A crystal structure led to the identification of a potent and novel CDK2 inhibitor, which exhibited an unusual mode of interaction with the kinase binding motif. With the aid of X-ray crystallography and modelling,