35106-84-4

Upstream product

• 57259-71-9 1-(1-hydroxyethyl)-2-hydroxymethylbenzene 
• 7789-60-8 phosphorus tribromide 
• 35050-24-9 2-(vinyl)benzyl acetate 
• 577-56-0 2-acetyl-benzoic acid 
• 611-14-3 2-Ethyltoluene 
• 35106-83-3 o-(α-Bromoethyl)benzylalkoholacetat 
• 125593-33-1 2-ethoxymethyl-phenethyl alcohol 

Downstream Products

• 42142-17-6 1-(o-tolyl)ethanamine 
• 35106-79-7 4-methyl-3-(3,4,5-trimethoxy-benzoyl)-3,4-dihydro-1H-benzo[d][1,2]oxazine 
• 35106-78-6 3-(2-chloro-benzoyl)-4-methyl-3,4-dihydro-1H-benzo[d][1,2]oxazine 
• 35106-77-5 3-(4-chloro-benzoyl)-4-methyl-3,4-dihydro-1H-benzo[d][1,2]oxazine 
• 35106-72-0 3-Chloroformyl-4-methyl-3,4-dihydro-1H-2,3-benzoxazin 
• 75820-08-5 1-methyl-2-(4-chloro-3-sulfamoylbenzamido)isoindoline 
• 932745-89-6 (2-benzyloxycarbonylamino-1-methyl-indan-2-yl)-phosphonic acid diethyl ester 
• 1083-04-1 2-Phenyl-1,2,3,4-tetrahydro-isoarsinolin 
• 136103-76-9 1-mercaptomethyl-2-(α-mercaptoethyl)benzene 
• 136103-73-6 4-methyl-cis-2-phenyl-1,3-dithia-5,6-benzocycloheptene 
• 19418-95-2 2-(2-ethylphenyl)acetic acid 

Relevant academic research and scientific papers

ISOINDOLINE DERIVATIVES

The present invention relates to isoindoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

Formation of 4,5,6,7-tetrahydroisoindoles by palladium-catalyzed hydride reduction

(Chemical Equation Presented) Substituted 1,3-dihydro-2H-isoindoles (2, isoindolines) were prepared and subjected to palladium-catalyzed formate reduction. Alkyl isoindolines were reduced to 4,5,6,7-tetrahydro-2H-isoindoles (1). Only partial reduction was observed for 5-methoxyisoindoline, and 4-methoxy-, 5-carbomethoxy-, amino-, and amidoisoindolines were inert to the reaction. Halogen-substituted isoindolines were dehalogenated and reduced to 4,5,6,7-tetrahydro-2H-isoindoles. Isoindole 24 was also reduced to a mixture of an isoindoline and a 4,5,6,7-tetrahydro-2H-isoindole. In contrast, 2,3-dihydro-1H-indoles 21 underwent dehydrogenation to give thermodynamically stable indoles. Theoretical calculations show the significant difference in aromaticity between isoindoles and indoles, corresponding to the observed differences in reactivities. Tetrahydro-2H-isoindoles 1 were oxidized to 4,5,6,7-tetrahydroisoindole-1,3-diones in the presence of NBS and air.

Inhibitors of phenylalanine ammonia-lyase: Substituted derivatives of 2-aminoindane-2-phosphonic acid and 1-aminobenzylphosphonic acid

Six derivatives of 2-aminoindane-2-phosphonic acid and 1-aminobenzylphosphonic acid were synthesized. The compounds were tested both as inhibitors of buckwheat phenylalanine ammonia-lyase (in vitro) and as inhibitors of anthocyanin biosynthesis (in vivo). (±)-2-Amino-4-bromoindane-2-phosphonic acid was found to be the strongest inhibitor from investigated compounds. The results obtained are a basis for design of phenylalanine ammonia-lyase inhibitors useful in the enzyme structure studies in photo labelling experiments.

Electro-organic reactions. Part 41. Diels-Alder reaction of o-quinodimethanes from the cathodic reduction of α,α'-dibromo-1,2-dialkylbenzenes

Cathodic reduction of α,α'-dibromo-1,2-dialkylbenzenes in DMF containing ET4N+ Br- as supporting electrolyte, in the presence of dienophiles (e.g. maleic anhydride derivatives), yielded Diels-Alder adducts of o-quinodimethanes. Selective reduction of the benzylic dibromides was often possible even when their irreversible cyclic voltammetric reduction peak potentials were more negative than the E(o) values for the anhydrides. This might be a consequence of redox catalysis, with the anhydrides having a dual role as mediators and dienophiles.

4,5 Dihydroimidazole compounds which have useful pharmaceutical utility

A compound of formula (I): STR1 or a pharmaceutically acceptable salt, ester or amide thereof, or a pharmaceutically acceptable solvate thereof, wherein: Z represents a residue of a substituted or unsubstituted aryl group, A1 represents a subst

STEREOCHEMISTRY OF SEVEN-MEMBERED HETEROCYCLES. XXVIII. 4-METHYL-1,3-DITHIO-5,6-BENZOCYCLOHEPTENES.

A series of dithioacetals were synthesized on the basis of 1-mercaptomethyl-2-(α-mercaptoethyl)benzene.It was established by 1H and 13C NMR methods that the cis-2-R-4-methyl derivatives (R=Ph, Me) are formed in the chair conformation.The introduction of a

Synthetic Applications of Intramolecular Insertion in Arylcarbenes. VI. Ylid Rearrangements in Pyrolysis of o-Alkylthiophenylcarbenes

Low-pressure thermal generation of a range of o-alkylthiophenylcarbenes produces, in addition to the normal insertion products, styrenes and 1,3-dihydrobenzothiophenes-clearly arising from rearrangement.The main features of their mechanism of formation are established by deuterium-labelling studies: in both cases participation by S-ylids implicated.