35107-12-1

Upstream product

• 504-21-2 (3S)-β-lysine 
• 501-53-1 benzyl chloroformate 
• 69677-00-5 N^α.N^δ-bis-benzyloxycarbonyl-L-ornithyl chloride 
• 2274-58-0 (S)-2,5-bis-(benzyloxycarbonylamino)pentanoic acid 
• 57133-27-4 (S)-N,N-dibenzyloxycarbonyl-β-lysine methyl ester 
• 37682-54-5 (S)-3,6-Bis-benzyloxycarbonylamino-hexanoic acid benzyl ester 

Downstream Products

• 58773-34-5 5-deoxy-3-epi-negamycine 
• 37682-54-5 (S)-3,6-Bis-benzyloxycarbonylamino-hexanoic acid benzyl ester 
• 504-21-2 (3S)-β-lysine 
• 83663-06-3 {5-[(2S,4S,5R,6R)-2-Allyloxy-4-hydroxy-6-hydroxymethyl-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyran-3-ylcarbamoyl]-4-benzyloxycarbonylamino-pentyl}-carbamic acid benzyl ester 
• 37682-58-9 (S)-6-Benzyloxycarbonylamino-3-((S)-3,6-bis-benzyloxycarbonylamino-hexanoylamino)-hexanoic acid methyl ester 

Relevant academic research and scientific papers

Tan-1057 derivatives

The invention relates to novel natural product derivatives of the formula (I), to processes for their preparation, to pharmaceutical compositions comprising them and to their use in the treatment of disorders in humans or animals: in which R1, D, X, Y and Z are defined as in claim 1.

Asymmetric Syntheses of the Naturally Ocurring β-Amino Acids, β-Lysine, β-Leucine and β-Phenyl-β-alanine via Nitrone Cycloaddition

A general asymmetric synthesis of β-amino acids is based on the dipolar cycloaddition of nitrones 7 (R* chiral) with vinyl acetate 8a, ketene acetals 8b or α-chloroacrylonitrile 8c.The cycloadducts 9 are converted either directly (9b) or via the isoxazolidones 10 (9a, 9c) into the free β-amino acids 11.Diastereoselectivity at C-3 in the adducts 9 ranges between 2:1 and 11:1.The natural β-amino acids, β-lysine, β-leucine and β-phenyl-β-alanine, have been prepared in this way.