35115-45-8Relevant articles and documents
Tandem [4 + 2]/[3 + 2] Cycloadditions with Nitroethylene
Denmark, Scott E.,Hurd, Alexander R.
, p. 3045 - 3050 (2007/10/03)
The simplest nitroalkene, nitroethylene, undergoes Lewis acid-promoted [4 + 2] cycloaddition with chiral vinyl ethers to afford cyclic nitronates with high diastereoselectivity. The resulting cyclic nitronates react with electron deficient alkenes to effect a face selective [3 + 2] cycloaddition. The origin of stereocontrol in the [3 + 2] cycloaddition is due to the single ring substituent, a remote acetal center. The scope and limitations of the use of nitroethylene as a 4π component in Lewis acid-promoted cycloadditions are documented and discussed. Additionally, concise syntheses of the pyrrolizidine alkaloids (+)-macronecine and (+)-petasinecine are presented.
Molecular modification of anticholinergics as probes for probes for muscarinic receptors. 3. Conformationally restricted analogues of benactyzine
Flavin,Lu,Thompson,Bhargava
, p. 278 - 285 (2007/10/02)
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