351157-86-3Relevant academic research and scientific papers
Synthesis, experimental and theoretical study on the structure of some semicarbazides with potential antibacterial activity
Pitucha, Monika,Karczmarzyk, Zbigniew,Kosikowska, Urszula,Malm, Anna
, p. 505 - 511 (2011/06/28)
A series of 1,4-disubstituted semicarbazide and 4,4'-bis[1-substituted semicarbazide]diphenyl-methane derivatives were synthesized to explore their antibacterial activity. New compounds were characterized by elemental analysis and spectroscopic data. In order to find the tautomeric equilibrium for the molecules energy calculations for each possible tautomeric form of model compound 2, and for the most antibacterially active compound 7 in the investigated series, were calculated for the gas phase at the RHF/SCF/6-31G** level of theory.
Determination of the lipophilicity of some new derivatives of semicarbazide and 1,2,4-Triazol-5-one with potential antibacterial activity
Pitucha, Monika,Polak, Beata,Swieboda, Ryszard,Kosikowska, Urszula,Malm, Anna
experimental part, p. 570 - 576 (2009/09/07)
The chromatographic behavior of new derivatives of 1,2,4-triazol-5-one and semicarbazide was determined. The lipophilicity was confirmed by the use of a RP-TLC method. The partition coefficients were calculated by use of theoretical procedures. The correl
