35124-22-2Relevant academic research and scientific papers
Total synthesis of (±)-petasitolone and (±)-fukinone
Pasikanti, Srinivas,Reddy, Dumbala Srinivasa,Iqbal, Javed,Dubey, Pramod Kumar,Das, Parthasarathi
experimental part, p. 3833 - 3837 (2010/03/04)
An efficient, general, and fully stereocontrolled synthesis of eremophilane-type compounds is disclosed. The approach features a highly diastereoselective Diels-Alder/aldol sequence to give a common intermediate, which is subsequently exploited to produce
The total synthesis of (+/-)-petasitolone
Liu, Hsing-Jang,Ngooi, Teng Ko
, p. 2676 - 2681 (2007/10/02)
The total synthesis of petasitolone (1), a sesquiterpenoid of the eremophilane family, has been accomplished.The key step of this efficient synthesis is the Lewis acid catalyzed Diels-Alder addition of 2-carbomethoxy-2-cyclohexenone (3) to diene 9.The cycloaddition, which gives adduct 16 in good yield, facilitates the rapid construction of the parent ring system of the target molecule and allows an excellent control of the required stereochemistry.
