3513-02-8

Basic information

• Product Name: (17S)-12β-Acetyloxy-3β,8,14,17-tetrahydroxypregn-5-en-20-one
• Synonyms: (17S)-12β-Acetyloxy-3β,8,14,17-tetrahydroxypregn-5-en-20-one;Metaplexigenin
• CAS NO: 3513-02-8
• Molecular Formula: C23H34O7
• Molecular Weight: 422.51186
• Mol File: 3513-02-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (17S)-12β-Acetyloxy-3β,8,14,17-tetrahydroxypregn-5-en-20-one(CAS DataBase Reference)
• NIST Chemistry Reference: (17S)-12β-Acetyloxy-3β,8,14,17-tetrahydroxypregn-5-en-20-one(3513-02-8)
• EPA Substance Registry System: (17S)-12β-Acetyloxy-3β,8,14,17-tetrahydroxypregn-5-en-20-one(3513-02-8)

Safety Data

• Hazardous Substances Data: 3513-02-8(Hazardous Substances Data)

Upstream product

• 1379657-70-1 metaplexigenin 3-O-β-D-glucopyranosyl-(1->4)-β-D-thevetopyranosyl-(1->4)-β-D-oleandropyranosyl-(1->4)-β-D-cymaropyranose 

Relevant articles and documents

Immunomodulating steroidal glycosides from the roots of Stephanotis mucronata

Guided by in vitro immunological tests, three immunomodulating steroidal glycosides, stemucronatosides A (1), B (2), and C (3), were isolated from the roots of Stephanotis mucronata. On the basis of chemical evidence and extensive spectroscopic methods including 1D and 2D NMR, their structures were determined as 12-O-deacetylmetaplexigenin 3-[O-6-deoxy-3-O-methyl-β-D-allopyranosyl-(1 → 4)-O-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside], 12-O-deacetylmetaplexigenin 3-[O-β-D-thevetopyranosyl-(1 → 4)-O-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside], and metaplexigenin 3-[O-β-D-glucopyranosyl-(1 → 4)-O-6-de-oxy-3-O-methyl- β-D-allopyranosyl-(1 → 4)-O-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside], respectively. These compounds showed immunomodulating activities in vitro.

Verticillosides A-M: Polyoxygenated pregnane glycosides from Asclepias verticillata L.

As part of our ongoing effort to explore the chemical diversity of plants of the United States Midwest region, the isolation and identification of 13 pregnane glycosides named verticillosides A-M from Asclepias verticillata L. are reported. The structures of these compounds were elucidated by various spectroscopic techniques, including 1D and 2D NMR, IR, UV, and HRMS. The cytotoxicity of the isolates was evaluated against paired breast cell lines Hs578T (cancer) and Hs578Bst (normal), however, no significant growth inhibition was observed.

Steroidal glycosides from the aerial part of Asclepias incarnata

The aerial part of Asclepias incarnata afforded 34 pregnane glycosides. These were confirmed to have lineolon, isolineolon, ikemagenin, 12-O- nicotinoyllineolon, deacylmetaplexigenin, metaplexigenin, rostratamine, 12-O- acetyllineolon, 15β-hydroxylineolon