351342-04-6

Basic information

• Product Name: PEG18
• Synonyms: HO-PEG17-OH
• CAS NO: 351342-04-6
• Molecular Formula: C34H70O18
• Molecular Weight: 766.9088
• Mol File: 351342-04-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 740.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.117±0.06 g/cm3(Predicted)
• Solubility: Soluble in Water, DMSO, DCM, DMF
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: PEG18(CAS DataBase Reference)
• NIST Chemistry Reference: PEG18(351342-04-6)
• EPA Substance Registry System: PEG18(351342-04-6)

Safety Data

• Hazardous Substances Data: 351342-04-6(Hazardous Substances Data)

Usage

Description

PEG18, also known as polyethylene glycol 18, is a synthetic polymer with a molecular weight of approximately 1000 Da. It contains repeating ethylene glycol subunits and two terminal hydroxyl groups, which can participate in reactions to further derivatize the compound. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media, with enhanced water solubility properties observed in longer PEG chains.

Uses

Used in Pharmaceutical Industry:
PEG18 is used as a solubility enhancer for poorly water-soluble drugs, improving their bioavailability and efficacy. The hydrophilic PEG chain aids in the dispersion of hydrophobic drug molecules in aqueous media, facilitating their absorption and distribution within the body.
Used in Cosmetics Industry:
PEG18 is used as a humectant and emollient in the cosmetics industry, providing moisturizing and skin-conditioning benefits. Its ability to increase water solubility and form hydrogen bonds with skin proteins helps maintain skin hydration and suppleness.
Used in Biomedical Applications:
PEG18 is used as a component in the synthesis of hydrogels and drug delivery systems, taking advantage of its water solubility and biocompatibility. These systems can be tailored for controlled drug release, targeting specific tissues or cells, and reducing systemic side effects.
Used in Chemical Synthesis:
PEG18 is used as a protecting group or a building block in the synthesis of various chemical compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its versatility and reactivity make it a valuable tool in organic synthesis and molecular engineering.
Used in Surface Modification:
PEG18 is used for surface modification of materials, such as nanoparticles, to improve their stability, biocompatibility, and stealth properties. The PEGylation process can reduce immunogenicity, aggregation, and non-specific interactions, enhancing the performance of these materials in various applications.