351354-33-1

Basic information

• Product Name: ethyl 3-chloro-2,4,5-trifluorobenzoate
• Synonyms: benzoic acid, 3-chloro-2,4,5-trifluoro-, ethyl ester
• CAS NO: 351354-33-1
• Molecular Formula: C₉H₆ClF₃O₂
• Molecular Weight: 238.5909
• Mol File: 351354-33-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 271.4°C at 760 mmHg
• Flash Point: 113.1°C
• Density: 1.416g/cm³
• Vapor Pressure: 0.00646mmHg at 25°C
• Refractive Index: 1.476
• CAS DataBase Reference: ethyl 3-chloro-2,4,5-trifluorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-chloro-2,4,5-trifluorobenzoate(351354-33-1)
• EPA Substance Registry System: ethyl 3-chloro-2,4,5-trifluorobenzoate(351354-33-1)

Safety Data

• Hazardous Substances Data: 351354-33-1(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 101513-77-3 3-Chloro-2,4,5-trifluorobenzoic acid 

Downstream Products

• 351355-02-7 4-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-3-chloro-2,5-difluoro-benzoic acid ethyl ester 
• 934394-48-6 4-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-3-chloro-2-cyclopropylamino-5-fluoro-benzoic acid 
• 934394-49-7 {1-[4-(N'-acetyl-hydrazinocarbonyl)-2-chloro-3-cyclopropylamino-6-fluoro-phenyl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester 
• 351359-01-8 N'-{4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoyl}-hydrazinecarboxylic acid tert-butyl ester 

Relevant articles and documents

Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors

A series of 3-aminoquinazolinediones was synthesized and evaluated for its antibacterial and DNA gyrase activity. The SAR around the quinazolinedione core was explored and the optimal substitutions were combined to give two compounds, 2r and 2s, with exceptional enzyme potency (IC50 = 0.2 μM) and activity against Gram-positive organisms (MIC's = 0.015-0.06 μ g/mL).