Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that possesses antiproliferative properties. It has the ability to inhibit the growth of various neuroblastoma and pancreatic cancer cells, while sparing normal human fibroblasts. Nemorosone induces apoptosis, modulates cell cycle progression, and activates the caspase cascade in cancer cells.
351416-47-2
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Basic information
- Product Name: nemorosone
- Synonyms: nemorosone
- CAS NO:351416-47-2
- Molecular Formula: C33H42O4
- Molecular Weight: 502.68
- EINECS: N/A
- Product Categories: N/A
- Mol File: 351416-47-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: nemorosone(CAS DataBase Reference)
- NIST Chemistry Reference: nemorosone(351416-47-2)
- EPA Substance Registry System: nemorosone(351416-47-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 351416-47-2(Hazardous Substances Data)
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351416-47-2 Usage
Uses
Used in Pharmaceutical Industry:Nemorosone is used as an anti-cancer agent for its ability to inhibit the growth of neuroblastoma and pancreatic cancer cells. It is effective against drug-resistant clones and induces apoptosis in a dose-dependent manner, making it a promising candidate for cancer treatment.
Used in Cancer Research:
Nemorosone is used as a research tool to study the mechanisms of apoptosis, cell cycle regulation, and the effects of MEK1/2 inhibition in neuroblastoma and pancreatic cancer cells. Its ability to modulate various signaling pathways and induce cell cycle arrest makes it valuable for understanding the molecular basis of cancer progression and potential therapeutic targets.
Used in Drug Development:
Nemorosone is used as a lead compound in the development of new anti-cancer drugs. Its selective toxicity towards cancer cells and its ability to activate the caspase cascade and inhibit cell cycle progression make it a promising starting point for the design of novel therapeutic agents targeting cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 351416-47-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,1,4,1 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.Calculate Digit Verification of CAS Registry Number 351416-47:
(8*3)+(7*5)+(6*1)+(5*4)+(4*1)+(3*6)+(2*4)+(1*7)=122
122 % 10 = 2
So 351416-47-2 is a valid CAS Registry Number.
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