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351436-77-6

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351436-77-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 351436-77-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,1,4,3 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 351436-77:
(8*3)+(7*5)+(6*1)+(5*4)+(4*3)+(3*6)+(2*7)+(1*7)=136
136 % 10 = 6
So 351436-77-6 is a valid CAS Registry Number.

351436-77-6Downstream Products

351436-77-6Relevant articles and documents

N-Aryl-N’-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes

Knutsson, Sofie,Kindahl, Tomas,Engdahl, Cecilia,Nikjoo, Dariush,Forsgren, Nina,Kitur, Stanley,Ekstr?m, Fredrik,Kamau, Luna,Linusson, Anna

, p. 415 - 427 (2017)

Vector control of disease-transmitting mosquitoes by insecticides has a central role in reducing the number of parasitic- and viral infection cases. The currently used insecticides are efficient, but safety concerns and the development of insecticide-resistant mosquito strains warrant the search for alternative compound classes for vector control. Here, we have designed and synthesized thiourea-based compounds as non-covalent inhibitors of acetylcholinesterase 1 (AChE1) from the mosquitoes Anopheles gambiae (An. gambiae) and Aedes aegypti (Ae. aegypti), as well as a naturally occurring resistant-conferring mutant. The N-aryl-N’-ethyleneaminothioureas proved to be inhibitors of AChE1; the most efficient one showed submicromolar potency. Importantly, the inhibitors exhibited selectivity over the human AChE (hAChE), which is desirable for new insecticides. The structure-activity relationship (SAR) analysis of the thioureas revealed that small changes in the chemical structure had a large effect on inhibition capacity. The thioureas showed to have different SAR when inhibiting AChE1 and hAChE, respectively, enabling an investigation of structure-selectivity relationships. Furthermore, insecticidal activity was demonstrated using adult and larvae An. gambiae and Ae. aegypti mosquitoes.

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