3515-46-6Relevant academic research and scientific papers
Iron-Catalyzed Direct Oxidative Alkylation and Hydroxylation of Indolin-2-ones with Alkyl-Substituted N-Heteroarenes
Feng, Yu,Han, Dong-Yang,Hu, Ren-Ming,Huang, Jie,Li, Ning,Xu, Da-Zhen
supporting information, p. 3876 - 3880 (2020/02/05)
Presented herein is the first direct alkylation and hydroxylation reaction between two different C(sp3)?H bonds, indolin-2-ones and alkyl-substituted N-heteroarenes, through an oxidative cross-coupling reaction. The reaction is catalyzed by a simple iron salt under mild ligand-free and base-free conditions. The reaction is environmentally benign, employs air (molecular oxygen) as the terminal oxidant and oxygen source for the synthesis of O-containing compounds, and produces only water as the byproduct.
A simple and sustainable tetrabutylammonium fluoride (TBAF)-catalyzed synthesis of azaarene-substituted 3-hydroxy-2-oxindoles through sp3 C-H functionalization
Kumari, Kumkum,Allam, Bharat Kumar,Singh, Krishna Nand
, p. 19789 - 19793 (2014/05/20)
A green, practical, and metal-free protocol for direct addition of α-and γ-alkylazaarenes to isatins has been developed via sp 3 C-H functionalization in water under controlled microwave radiation. This methodology provides a mild and fast rout
A novel and efficient synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via sp3 C-H functionalization of 2-methyl azaarenes and (2-azaaryl)methanes over a heterogeneous, reusable silica-supported dodecatungstophosphoric acid catalyst
Mulla, Shafeek A. R.,Pathan, Mohsinkhan Y.,Chavan, Santosh S.
, p. 20281 - 20286 (2013/11/06)
A novel and efficient protocol has been developed for the synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via sp3 C-H functionalization of 2-methyl azaarenes and (2-azaaryl)methanes with isatin in good to excellent yield. This is the fi
Chemistry of indoles carrying a basic function, Part 3. Synthesis of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H)-ones with antihypoxic effects
Moldvai,Gacs-Baitz,Balazs,Incze,Szantay
, p. 541 - 549 (2007/10/03)
Hydroxyindolones (1-6, 15-16) were transformed into isatinylidenes (7,9-13, 17-19) by dehydration with 4-toluenesulfonic acid. The dimer-type compounds (14, 20) were also isolated in a few cases. The obtained isatinylidenes were transformed into 3-spiro-cyclopropane-oxindoles (21-32) with dimethyloxosulfonium methylide. Compound 22 shows protective effects against hypobaric hypoxia and triethyltin induced brain edema.
