35150-09-5

Basic information

• Product Name: BOC-GLY-NH2
• Synonyms: BOC-GLY-NH2;TERT-BUTYL CARBAMOYLMETHYLCARBAMATE;TERT-BUTYL 2-AMINO-2-OXOETHYLCARBAMATE;Boc-Glycinamide;N-tert-Butoxycarbonyl-L-glycinamide;N-Boc-glycinaMide, 95%;tert-butyl N-(2-amino-2-oxoethyl)carbamate;(Tert-Butoxy)Carbonyl Gly-NH2
• CAS NO: 35150-09-5
• Molecular Formula: C₇H₁₄N₂O₃
• Molecular Weight: 174.2
• EINECS: 1533716-785-6
• Mol File: 35150-09-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 85-87 °C
• Boiling Point: 339.677 °C at 760 mmHg
• Flash Point: 159.2 °C
• Appearance: White/Solid
• Density: 1.108 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.464
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 12.01±0.46(Predicted)
• CAS DataBase Reference: BOC-GLY-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-GLY-NH2(35150-09-5)
• EPA Substance Registry System: BOC-GLY-NH2(35150-09-5)

Safety Data

• Hazardous Substances Data: 35150-09-5(Hazardous Substances Data)

Usage

Uses

Boc-Glycinamide is a useful synthetic intermediate. It is used to prepare primary amides as selective inhibitors of cathepsin K. It is also used to prepare group A streptococcal vaccine.

InChI:InChI=1/C7H14N2O3/c1-7(2,3)12-6(11)9-4-5(8)10/h4H2,1-3H3,(H2,8,10)(H,9,11)

Upstream product

• 3655-05-8 tert-butoxycarbonylglycine p-nitrophenylester 
• 31954-27-5 N-(tert-butoxycarbonyl)glycine methyl ester 
• 50903-47-4 perfluorophenyl 2-((tert-butoxycarbonyl)amino)acetate 

Downstream Products

• 186453-48-5 2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester 
• 182120-87-2 2-tert-butoxycarbonylaminoacetimidic acid ethyl ester 
• 85363-04-8 tert-butyl cyanomethylcarbamate 
• 479079-15-7 tert-butyl [2-amino-2-(hydroxyimino)ethyl]carbamate 
• 871715-97-8 tert-butyl N-[(4-benzylthiazol-2-yl)methyl]carbamate 
• 1416507-56-6 C₄₄H₅₅N₅O₁₅ 
• 34885-75-1 <(tert-butyloxycarbonyl)amino>-N-(4-methoxyphenyl)acetamide 
• 153407-40-0 (+/-)-2-(tert-butoxycarbonyl)-amino-N-[(2,6-dimethyl)phenyl]acetamide 
• 1387882-10-1 C₁₆H₂₄N₂O₃ 
• 1387753-63-0 C₁₅H₂₂N₂O₃ 

Relevant articles and documents

RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles

The established cytotoxic agent RITA contains a thiophene-furan-thiophene backbone and two terminal alcohol groups. Herein we investigate the effect of using thiazoles as the backbone in RITA-like molecules and modifying the terminal groups of these trithiazoles, thereby generating 41 unique structures. Incorporating side chains with varied steric bulk allowed us to investigate how size and a stereocenter impacted biological activity. Subjecting compounds to growth inhibition assays on HCT-116 cells showed that the most potent compounds 7d, 7e, and 7h had GI50 values of 4.4, 4.4, and 3.4 μM, respectively, versus RITA (GI50 of 800 nM). Analysis of these compounds in apoptosis assays proved that 7d, 7e, and 7h were as effective as RITA at inducing apoptosis. Evaluating the impact of 7h on proteins targeted by RITA (p53, c-Myc, and Mcl-1) indicated that it acts via a different mechanism of action to that of RITA. RITA suppressed Mcl-1 protein via p53, whereas compound 7h suppressed Mcl-1 expression via an alternative mechanism independent of p53.

NATURAL PEPTIDES AND THEIR ANALOGS. XXX. INFLUENCE OF THE NATURE OF THE SOLVENT ON THE KINETICS OF HYDROLYSIS, AMONOLYSIS, AND ALCOHOLYSIS REACTIOS OF ACTIVATED ESTERS OF (tert-BUTOXYCARBONYL)GLYCINE

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