351513-84-3Relevant academic research and scientific papers
Synthesis, crystal structures and xanthine oxidase inhibitory activity of benzohydrazone compounds
Zhang, Wei-Ming,Sheng, Gui-Hua,Zhonglu, You
, p. 8118 - 8122 (2014)
A series of three benzohydrazone compounds, 2N′-(5-hydroxy-2-nitrobenzylidene)-4-methylbenzohydrazide (1), N′-(5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide (2) and N′-(2,4-dichlorobenzylidene)-3-methylbenzohydrazide (3 ), were prepared and structurally characterized by elemental analysis, IR spectra and single crystal X-ray determination. Xanthine oxidase inhibitory activities of the compounds were studied. Among the compounds, N′-(5-hydroxy-2-nitrobenzylidene)-4-methylbenzohydrazide (1) shows the most effective activity with IC50 value of 15.2 ± 2.3 μM. Docking simulation was performed to insert the compound into the crystal structure of xanthine oxidase at the active site to investigate the probable binding modes.
SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER
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Page/Page column 125, (2010/08/08)
The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of fungi.
