35160-70-4

Upstream product

• 52186-81-9 (R)-2-((2R)-2r-hydroxysulfanyl-4-oxo-3c-phthalimido-azetidin-1-yl)-3-methyl-but-3-enoic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

Unusually stable azetidinone sulfenic acids

Sulfoxides of (2S,5S,6S)-penams rearrange upon heating in benzene or toluene to form unusually stable azetidinone sulfenic acids. A reversal of the process, the annelation of the sulfenic acids, is disfavoured due to steric congestion on the endo-face of the corresponding penam sulfoxides.