35162-23-3

Upstream product

• 6341-92-0 6-chloroisatin 

Downstream Products

• 121006-70-0 2-(7-Chloro-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-1-phenyl-ethanone; hydrochloride 
• 121006-69-7 1-(4-Bromo-phenyl)-2-(7-chloro-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-ethanone; hydrobromide 
• 121006-77-7 7-Chloro-3-phenyl-1-thia-3a,4,9,10-tetraaza-cyclopenta[b]fluorene 
• 121006-76-6 3-(4-Bromo-phenyl)-7-chloro-1-thia-3a,4,9,10-tetraaza-cyclopenta[b]fluorene 
• 121006-78-8 7-Chloro-3-(4-chloro-phenyl)-1-thia-3a,4,9,10-tetraaza-cyclopenta[b]fluorene 
• 121006-79-9 3-Biphenyl-4-yl-7-chloro-1-thia-3a,4,9,10-tetraaza-cyclopenta[b]fluorene 
• 121006-71-1 1-(4-Chloro-phenyl)-2-(7-chloro-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-ethanone; hydrobromide 

Relevant academic research and scientific papers

Condensed heterocyclic systems: Synthesis and antimicrobial activity of a few heterocycles derived from 7-chloro-5H-2, 3-dihydro-1,2,4-triazino[5, 6-b]indole-3-thione

7-Chloro-5H-2, 3-dihydro-1, 2, 4-triazino[5, 6-b]indole-3-thione (II) on condensation with 1, 2-dibromoethane, 1, 3-dibromopropane and 2, 3-dichloroquinoxaline gives the cyclized products 8-chloro-2 3-dihydrothiazolo[3', 2'; 2,3][1, 2, 4]triazino[5, 6-b]indole (III), 9-chloro-4H-2, 3-dihydro[1,3]thiazino[3', 2':2, 3][1,2,4]triazino[5,6-b]indole (IV) and 10-chloroquinoxalino[2', 3':4,5]thiazolo[3,2-b]indolo]2,3-e][1, 2,4]triazine (V) respectively and not the angular isomers VI, VII and VIII. The unequivocal synthesis of the latter (VI, VII and VIII) has been accomplished by the reaction of 6-chloroisatin-3-thiosemicarbazone (1) with 1,2-dibromoethane, 1,3-dibromopropane and 2,3-dichloroquinoxaline respectively. The antibacterial and antifungal activities of the synthesized compounds have been evaluated.

Heterocyclic Systems Containing Bridgehead Nitrogen Atom: Synthesis of Thiazolotriazinoindoles and Isomeric Thiazolotriazinoindoles

8-Bromo- and 7-chloro-5H-2,3-dihydrotriazinoindole-3-thiones (II) on condensation with α-halogenoketones give 5H-3-aroylmethylthio-8-bromo- and 5H-3-aroylmethylthio-7-chlorotriazinoindole hydrohalides (III) which undergo PPA cyclization to furnish 3-aryl-7-bromo- and 3-aryl-8-chloro-thiazolotriazinoindoles (IV) and not the angular isomeric 1-aryl-7-bromo- and 1-aryl-8-chloro-thiazolotriazinoindoles (VI).The unequivocal synthesis of the latter (VI) has also been accomplished.