351903-01-0

Upstream product

• 99-73-0 para-bromophenacyl bromide 
• 586-75-4 4-chlorobenzoyl chloride 
• 89-51-0 Homophthalic acid 
• 118520-88-0 3-(4-bromophenyl)-1H-2-benzopyran-1-one 

Downstream Products

• 351903-05-4 2-[2-(4-bromo-phenyl)-2-hydroxy-ethyl]-benzoic acid 
• 118520-88-0 3-(4-bromophenyl)-1H-2-benzopyran-1-one 

Relevant academic research and scientific papers

Five- and six-membered nickelacyclic carboxylates as reagents for the facile synthesis of δ-ketocarboxylic acids, isocoumarins, and 1,3-dicarbonyl derivatives of benzoic acid

The nickelacyclic carboxylates A and B reacted with α-halo ketones to form α,β-unsaturated δ-ketocarboxylic acids which were easily converted into pyranones or isocoumarins. In addition, reaction of the nickelacyclic acyl derivative C with α-halo ketones

Synthesis of some new 3-(bromophenyl)isocoumarins and their conversion to (dl)-3,4-dihydroisocoumarins

3-(Bromophenyl)isocoumarins 8a-c have been synthesized by the condensation of homophthalic acid 6 with bromobenzoyl chlorides 7a-c which on alkaline hydrolysis give keto-acids 9a-c. (dl)-3-(Bromophenyl)-3,4-dihydroisocoumarins 12a-c are obtained by reduct