35196-11-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-5-(methylsulfonyl)pyridine is used as an intermediate in the synthesis of various pharmaceuticals for its potential applications in the development of new drugs.
Used in Agrochemical Industry:
2-Amino-5-(methylsulfonyl)pyridine is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective products for agricultural applications.
Used in Research and Development:
2-Amino-5-(methylsulfonyl)pyridine is used as a building block in research and development activities within the pharmaceutical and agrochemical industries, aiding in the creation of compounds with biological activity.

Upstream product

• 20511-12-0 2-amino-5-iodopyridine 
• 2386-57-4 methanesulfonic acid sodium salt 
• 20277-69-4 sodium methansulfinate 
• 35196-10-2 5-(methylsulfonyl)-2-nitropyridine 
• 35196-09-9 5-(methylthio)-2-nitropyridine 
• 52092-47-4 5-chloro-2-nitropyridine 
• 77618-99-6 2-amino-5-(methylthio)pyridine 

Downstream Products

• 1360055-04-4 6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[5-(5-methanesulfonyl-pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES

Compounds having the structure of Formula (I) or pharmaceutically acceptable isomers, racemates, hydrates, solvates or salts thereof, where A, R1, R2a, R2b, R2c and R3 are as defined herein, are usefu

HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE

Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being described in the specifications. The compound represented by formula (I) can be used as the ligand in the copper catalyzed coupling reaction of the aryl halogeno substitute, and is used or catalyzing the coupling reaction for forming the aryl halogeno substitute having C—N, C—O, C—S and other bonds.

A Class of Amide Ligands Enable Cu-Catalyzed Coupling of (Hetero)aryl Halides with Sulfinic Acid Salts under Mild Conditions

The amide derived from 4-hydroxy-l-proline and 2,6-dimethylaniline is a powerful ligand for Cu-catalyzed coupling of (hetero)aryl halides with sulfinic acid salts, allowing the formation of a wide range of (hetero)aryl sulfones from the corresponding (hetero)aryl halides at considerably low catalytic loadings. The coupling of (hetero)aryl iodides and sodium methanesulfinate proceeds at room temperature with only 0.5 mol % CuI and ligand, representing the first example for Cu-catalyzed arylation at both low catalytic loading and room temperature.

HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY

Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X, and Xare N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I foranddiagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Substituted imidazolo-pyridines and method

Imidazolo-pyridine derivatives are provided having the structure STR1 wherein R is lower alkyl, lower alkenylalkyl, lower alkynylalkyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl or phenylalkyl and R1 is lower alkyl, phenylalkyl or di-lower alkylaminoalkyl and n is 0, 1 or 2. These compounds are useful as anthelmintic agents administered orally or parenterally.