351982-44-0

Basic information

• Product Name: 4-(4-ISOBUTYLPHENYL)-1,3-THIAZOL-2-AMINE
• Synonyms: 4-(4-ISOBUTYLPHENYL)-1,3-THIAZOL-2-AMINE;4-(4-isobutylphenyl)-1,3-thiazol-2-amine(SALTDATA: FREE)
• CAS NO: 351982-44-0
• Molecular Formula: C13H16N2S
• Molecular Weight: 232.35
• Mol File: 351982-44-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 391°C at 760 mmHg
• Flash Point: 190.3°C
• Appearance: /
• Density: 1.128g/cm³
• Vapor Pressure: 2.54E-06mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 4-(4-ISOBUTYLPHENYL)-1,3-THIAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-ISOBUTYLPHENYL)-1,3-THIAZOL-2-AMINE(351982-44-0)
• EPA Substance Registry System: 4-(4-ISOBUTYLPHENYL)-1,3-THIAZOL-2-AMINE(351982-44-0)

Safety Data

• Hazardous Substances Data: 351982-44-0(Hazardous Substances Data)

Usage

General Description

4-(4-Isobutylphenyl)-1,3-thiazol-2-amine is a chemical compound with the molecular formula C13H18N2S. It is a thiazole derivative that contains an amine group, and it is commonly used in organic synthesis and medicinal chemistry. Thiazoles are an important class of heterocyclic compounds that have various biological activities, and they are found in many natural products and pharmaceuticals. The presence of the isobutylphenyl group in 4-(4-Isobutylphenyl)-1,3-thiazol-2-amine gives the compound specific structural and pharmacological properties, making it useful for the development of drugs and other bioactive molecules. 4-(4-ISOBUTYLPHENYL)-1,3-THIAZOL-2-AMINE may serve as a valuable building block for the synthesis of new pharmaceuticals and other potentially useful compounds.

InChI:InChI=1/C13H16N2S/c1-9(2)7-10-3-5-11(6-4-10)12-8-16-13(14)15-12/h3-6,8-9H,7H2,1-2H3,(H2,14,15)

Upstream product

• 38861-78-8 1-(4-isobutyl-phenyl)-ethanone 
• 17356-08-0 thiourea 
• 538-93-2 1-phenyl-2-methylpropane 
• 56374-25-5 4-(isobutyl)phenacyl chloride 

Relevant articles and documents

Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile

Two series of new thiazolidin-4-one derivatives 4a-c and 8a-e were designed and prepared. All the synthesized compounds were evaluated for their in vitro COX-2 selectivity and anti-inflammatory activity in vivo. Compounds 8c and 8d showed the best overall

PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS

The present invention is related to novel pyrimidinedione-fused heterocyclic compounds as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

Bismuth chloride mediated synthesis, antimicrobial, and anti-inflammatory activities of new 4-aryl-2-amino thiazoles

Synthesis of 4-aryl-2-Amino thiazoles (3a-u), (4a-c), and (5a-c) was achieved from the reaction of 4-butyl phenacyl chlorides (2a-c) with N-substituted thioureas, in the presence of Bismuth Chloride. The antimicrobial and anti-inflammatory activities of the final products were also studied. Copyright Taylor & Francis Group, LLC.