351982-44-0

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-Isobutylphenyl)-1,3-thiazol-2-amine is used as a building block for the development of new pharmaceuticals due to its specific structural and pharmacological properties.
Used in Organic Synthesis:
4-(4-Isobutylphenyl)-1,3-thiazol-2-amine is used as a key intermediate in the synthesis of various organic compounds, including bioactive molecules and other potentially useful compounds.

InChI:InChI=1/C13H16N2S/c1-9(2)7-10-3-5-11(6-4-10)12-8-16-13(14)15-12/h3-6,8-9H,7H2,1-2H3,(H2,14,15)

Upstream product

• 38861-78-8 1-(4-isobutyl-phenyl)-ethanone 
• 17356-08-0 thiourea 
• 538-93-2 1-phenyl-2-methylpropane 
• 56374-25-5 4-(isobutyl)phenacyl chloride 

Relevant academic research and scientific papers

Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile

Two series of new thiazolidin-4-one derivatives 4a-c and 8a-e were designed and prepared. All the synthesized compounds were evaluated for their in vitro COX-2 selectivity and anti-inflammatory activity in vivo. Compounds 8c and 8d showed the best overall

FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS

The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl. Formula (I)

PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS

The present invention is related to novel pyrimidinedione-fused heterocyclic compounds as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS

The present invention provides Quinazolinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by T

Bismuth chloride mediated synthesis, antimicrobial, and anti-inflammatory activities of new 4-aryl-2-amino thiazoles

Synthesis of 4-aryl-2-Amino thiazoles (3a-u), (4a-c), and (5a-c) was achieved from the reaction of 4-butyl phenacyl chlorides (2a-c) with N-substituted thioureas, in the presence of Bismuth Chloride. The antimicrobial and anti-inflammatory activities of the final products were also studied. Copyright Taylor & Francis Group, LLC.

Aminothiazoles: Part 1 - Syntheses and pharmacological evaluation of 4-[isobutylphenyl]-2-substituted-aminothiazoles

Unreported p-isobutyl phenacyl chloride has been prepared by the reaction of chloroacetyl chloride on isobutyl benzene. It is condensed with thiourea and its derivatives to get the title compounds. The products obtained are characterized by their IR, sup