35202-16-5

Upstream product

• 3686-57-5 2,4-dimethoxy-6-methylbenzoic acid 

Downstream Products

• 914298-87-6 (3-chloro-4,6-dimethoxy-2-methylphenyl)(isoindolin-2-yl)methanone 
• 68048-21-5 3,3'-Dichlor-6-hydroxy-2,4,4',6'-tetramethoxy-2'-methyl-benzophenon 
• 75177-70-7 2-(carboxymethyl)-3-chloro-4,6-dimethoxybenzoic acid 
• 55044-85-4 5-chloro-8-hydroxy-6-methoxy-3-methylisocoumarin 
• 68048-20-4 6-Benzyloxy-3,3'-dichlor-2,4,4',6'-tetramethoxy-2'-methyl-benzophenon 
• 914299-81-3 3-chloro-4,6-dimethoxy-2-(2-methoxy-2-oxoethyl)benzoic acid 

Relevant academic research and scientific papers

MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90

Disclosed are macrocyclic compounds of formulae I-V,which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90.

AMIDE RESORCINOL COMPOUNDS

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.