35203-91-9

Usage

Uses

Used in Organic Synthesis:
8-Quinolinesulfonamide is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the formation of a wide range of derivatives, making it a valuable building block in the development of new chemical entities.
Used in Pharmaceutical Industry:
8-Quinolinesulfonamide is used as a potential antimicrobial agent for the development of new drugs. Its antimicrobial properties make it a promising candidate for the treatment of bacterial infections, especially in the context of increasing antibiotic resistance.
Used in Research and Development:
8-Quinolinesulfonamide is used as a research compound in the study of its chemical properties, potential applications, and therapeutic effects. This helps in understanding its role in various biological processes and its potential as a therapeutic agent in different medical fields.

InChI:InChI=1/C9H8N2O2S/c10-14(12,13)8-5-1-3-7-4-2-6-11-9(7)8/h1-6H,(H2,10,12,13)

Upstream product

• 61081-36-5 8-quinolinesulfinic acid sodium salt 
• 18704-37-5 quinoline-8-sulfonyl chloride 

Downstream Products

• 18704-37-5 quinoline-8-sulfonyl chloride 
• 1017610-00-2 N-(8-quinolinesulfonyl)phenylaziridine 
• 948844-37-9 N-benzylidene-8-quinolinesulfonamide 
• 1087163-27-6 (E)-N-(4-chlorobenzylidene)-N-[(8-quinolyl)sulfonyl]imine 
• 872874-36-7 (E)-N-benzylidene-N-[(8-quinolyl)sulfonyl]imine 
• 1087163-26-5 (E)-N-(4-methoxybenzylidene)-N-[(8-quinolyl)sulfonyl]imine 
• 1087163-28-7 (E)-N-(2-methylbenzylidene)-N-[(8-quinolyl)sulfonyl]imine 

Relevant academic research and scientific papers

Ionization constants of all seven positional isomers of quinolinesulfonamides and quinoline-N,N-dimethylsulfonamides

The pKa values of isomeric sulfamoylquinolines 2a-8a and N,N-dimethylsulfamoylquinolines 2b-8b were determined by means of a UV-VIS spectroscopic method that uses absorbance diagrams, at constant ionic strength (0.15 M). For sulfamoylquinolines 2a-8a two pKa values - for basic function (Nring: -0.31 to 3.36) and for acid function (SO 2NH2 group: 8.89-10.34) but only one in the case of N,N-dimethylsulfamoylquinolines 2b-8b (-0.05 to 3.07) - were obtained. The full geometry optimization in the 6-311 + G(d) basis set and the NBO population analysis were performed. Correlation between the experimentally determined and theoretically calculated (Sparc program) of pKa values as well as the differences between the calculated NBO population values for neutral and ionic forms were found for compounds 2a-7a and 2b-8b.

Sulfonamide formation from sodium sulfinates and amines or ammonia under metal-free conditions at ambient temperature

A novel, practical and highly efficient method for the construction of a variety of sulfonamides mediated by I2 was demonstrated. The reaction proceeds readily at room temperature using a variety of sodium sulfinates and amines or ammonia in water in a metal-, base-, ligand-, or additive-free protocol. Primary, secondary and tertiary sulfonamides were obtained in good to excellent yields with a broad range of functional group tolerability. This journal is

Compounds for the Treatment of Hepatitis C

The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

From haloquinolines and halopyridines to quinoline- and pyridinesulfonyl chlorides and sulfonamides

The action of sodium methanethiolate (in boiling DMF) towards haloazines (i.e. chloro- or bromo-pyridines and quinolines) (1) (with halogen substituent in non-aza-activated position) causes sequentially halogen ipso-substitution to methylthioazines (2) and then S-demethylation to azinethiolates (3A), which were: i) subjected to S-methylation, ii) oxidized to diazinyl disulfides (4) and iii) oxidatively chlorinated to azinesulfonyl chlorides (5). α- and γ-pyridine- and quinolinesulfonyl chlorides (5a, 5c, 5d and 5f) were prepared by oxidative chlorination of respective disulfides (4) performed in conc. hydrochloric acid and characterized by 1H and 13C NMR spectra. All azinesulfonyl chlorides (5) were effectively converted to corresponding azinesulfonamides (6).