352196-57-7Relevant academic research and scientific papers
Ultrasound-promoted synthesis of 2,3-bis(4-hydroxyphenyl)indole derivatives as inherently fluorescent ligands for the estrogen receptor
Koulocheri, Sophia D.,Haroutounian, Serkos A.
, p. 1723 - 1729 (2007/10/03)
A series of 2,3-bis(4-hydroxyphenyl)indole derivatives 4c-f was prepared by ultrasound-promoted intramolecular cyclodehydration of a polyphosphoric acid solution of α-anilinyl-(or 3-anisidyl)desoxyanisoins 2c-f, and their optical spectroscopy and estrogen receptor (ER) binding properties were studied. Compounds 4c-f give intense long-wavelength fluorescent emission, sensitive to solvent polarity and pH. Furthermore, the two indol-6-ols 4e, f display reasonably good binding affinities to ER and appear to be well suited for use as fluorescent probes for the detection of ER in cells.
