352213-95-7Relevant academic research and scientific papers
Synthesis of new fluorinated derivatives of quinolinecarboxylic acids
Nosova,Sidorova,Lipunova,Mochul'skaya,Chasovskikh,Charushin
, p. 922 - 928 (2007/10/03)
Ethyl esters of 1-(7-Z-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carbamoyl-5-X-6,7, 8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids (X = H, F; Z = pyrrolidino-, piperidino-, hexamethylenimino-, morpholino-, thiomorpholino-) have been synthesized by the interaction of quinolone-3-carboxylic acid hydrazides with ethyl esters of 3-ethoxy-2-(polyfluorobenzoyl)acrylic acid. It was shown possible to cyclize intramolecularly the esters obtained with the formation of 1,3,4-oxadiazino[6,5,4-i.j]quinoline derivatives.
