352214-93-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-5,6-difluorobenzothiazole is used as a key intermediate in the synthesis of various pharmaceuticals for its unique chemical properties and potential biological activity. Its derivatives have been investigated for their therapeutic potential, making it a valuable component in drug discovery and development.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Amino-5,6-difluorobenzothiazole serves as a crucial building block in the synthesis of various agrochemicals. Its unique structure and properties contribute to the development of effective and targeted agrochemical products.
Used in Organic Synthesis:
2-Amino-5,6-difluorobenzothiazole is used as a versatile intermediate in organic synthesis, enabling the preparation of a wide range of functional materials. Its unique structure and reactivity make it an essential component in the synthesis of various valuable products.
Used in Drug Discovery and Development:
Due to its biological activity, 2-Amino-5,6-difluorobenzothiazole and its derivatives are extensively studied for their potential applications in drug discovery and development. Researchers explore their therapeutic properties and mechanisms of action to identify new drug candidates for various diseases and conditions.

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 3863-11-4 3,4-difluoroaniline 

Downstream Products

• 131105-93-6 4,5-difluoro-2-aminothiophenol 
• 912273-97-3 N-(5,6-difluoro-1,3-benzothiazol-2-yl)-2,3,4,5-tetrafluorobenzamide 
• 960535-39-1 C₇H₂ClF₂NS 
• 1374820-31-1 C₁₇H₁₅Cl₂F₂N₃S 
• 1430750-41-6 tert-butyl 3-(1-benzyl-1H-pyrazol-4-yl)-6-(8-(5,6-difluorobenzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinate 

Relevant academic research and scientific papers

PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OF ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Provided is a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives

In this study, a novel benzothiazol- and benzooxazol-2-amine scaffold with antibacterial activity was designed and synthesized. Preliminary structure-activity relationship analysis displayed that compound 8t with a 5,6-difluorosubstituted benzothiazole was found to be a potent inhibitor of Gram-positive pathogens, and exhibited some potential against drug-resistant bacteria and without cytotoxicity in therapeutic concentrations. In addition, molecular docking studies indicated that Staphylococcus aureus methionyl-tRNA synthetase might be the possible target of these compounds. Taken together, the present study provides an effective entry to the synthesis of a good lead for subsequent optimization and a new small molecule candidate drug for antibacterial therapeutics.

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to a series of compounds useful for inhibiting histone deacetylase (HDAC) enzymatic activity. The invention also provides a method for inhibiting histone descetylase in a cell using said compounds as well as a method for treating cell proliferative diseases and conditions using said HDAC inhibitors. Further, the invention provides pharmaceutical compositions comprising the HDAC inhibiting compounds and a pharmaceutically acceptable carrier.

Synthesis of some 5-nitro-2-furfurylidene derivatives and their antibacterial and antifungal activities

A number of new 5-nitro-2-furfurylidene derivatives 9a-k were synthesized by the reaction of 2-methyl-4-(5-nitro-2-furfurylmethyliden)-Δ2-oxazolin-5-one 6 or 2-phenyl-4-(2-furfurylmethyliden)-Δ2-oxazolin-5-one 7 with appropriate 2-aminobenzothiazole. The compounds synthesized were identified by 1H-NMR, IR, MS and micro analysis. All compounds studied in this work were screened for their in vitro antimicrobial and antifungal activities against the standard strains: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, and the yeast Candida albicans.