35227-77-1

Upstream product

• 20319-44-2 dimethyl 5-methoxyisophthalate 
• 618-83-7 5-Hydroxyisophthalic acid 
• 13036-02-7 Dimethyl 5-hydroxyisophthalate 
• 46331-50-4 5-methoxyisophthalic acid 

Downstream Products

• 221626-96-6 5-methoxy-N,N'-dipropyl-isophthalamide 
• 150959-54-9 3,5-bis(4-fluorobenzoyl)anisole 
• 349546-89-0 3,5-bis-[5-(3,5-di-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenol 
• 349546-87-8 C₃₉H₄₈N₄O₃ 
• 114274-46-3 3,5-bis(benzylcarbamoyl)anizole 
• 201734-78-3 ethyl 5-(ethoxycarbonyl)-3-methoxybenzoate 
• 20319-44-2 dimethyl 5-methoxyisophthalate 

Relevant academic research and scientific papers

Effect of Hydrogen Binding on Selective Recognition of Halide Anions

The interplay of molecular rigidity enforced by interior or exterior hydrogen bonding and affinity for binding halide anions is described to demonstrate the effect of intramolecular hydrogen bonding in anion recognition process. To this end pyridine-2,6-d

Convergent Ditopic Receptors Enhance Anion Binding upon Alkali Metal Complexation for Catalyzing the Ritter Reaction

A supramolecular approach to catalyzing the Ritter reaction by utilizing enhanced anion-binding affinity in the presence of alkali metal cations was developed with ditopic hydrogen-bonded amide macrocycles. With prebound cations in the macrocycle, particu

Highly Selective Carbon Dioxide Capture and Cooperative Catalysis of a Water-Stable Acylamide-Functionalized Metal–Organic Framework

Incorporation of specific functionalities within the framework offers a significant opportunity to produce high-performance gas storage/separation and catalysis MOF materials. In this work, multifunctionalities, including hydrophobic methoxy groups, polar acylamide functionalities, and open copper(II) sites, have been successfully integrated into a twofold interpenetrated microporous MOF (HNUST-6, HNUST represents Hunan University of Science and Technology). HNUST-6 possesses permanent porosity, with a moderate BET surface area of 1093 m2 g–1 and high CO2 adsorption capacity (111 cm3 g–1 at 1 bar), with good selectivity for CO2 over CH4 (6.6) and N2 (30.3) at 273 K. Remarkably, this MOF material exhibits excellent water stability and its framework structure is retained after being immersed in boiling water. In addition, HNUST-6 demonstrates efficient catalytic activity as a cooperative catalyst in a tandem one-pot deacetalization Knoevenagel condensation reaction.

Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum

Quinoline antimalarials target hemozoin formation causing a cytotoxic accumulation of ferriprotoporphyrin IX (Fe(III)PPIX). Well-developed SAR models exist for β-hematin inhibition, parasite activity, and cellular mechanisms for this compound class, but no comparably detailed investigations exist for other hemozoin inhibiting chemotypes. Here, benzamide analogues based on previous HTS hits have been purchased or synthesized. Only derivatives containing an electron deficient aromatic ring and capable of adopting flat conformations, optimal for π-π interactions with Fe(III)PPIX, inhibited β-hematin formation. The two most potent analogues showed nanomolar parasite activity, with little CQ cross-resistance, low cytotoxicity, and high in vitro microsomal stability. Selected analogues inhibited hemozoin formation in Plasmodium falciparum causing high levels of free heme. In contrast to quinolines, introduction of amine side chains did not lead to benzamide accumulation in the parasite. These data reveal complex relationships between heme binding, free heme levels, cellular accumulation, and in vitro activity of potential novel antimalarials.

Bispyrrolylbenzene anion receptor: From supramolecular switch to molecular logic gate

We have designed anion receptor 4 based on a conformationally labile bispyrrolylbenzene framework, the conformation of which can be changed by appropriate anionic stimuli. In the absence of fluoride anion, the pyrrole moieties rotate freely at room temperature. However, when the concentration of fluoride anion exceeds 2 equivalents, the rotation of the pyrrole units slows down and the conformation of the receptor changes to anti-anti. DFT calculations have shown that this change is due to binding of a third fluoride anion through C-H interaction. Anion receptor 4 can also serve as a molecular logic gate. Anionic inputs such as fluoride and dihydrogenphosphate allow the realization of INHIBIT and NAND logic gate functions with absorption and fluorescence as readouts, respectively.

Polycyanurate networks with enhanced segmental flexibility and outstanding thermochemical stability

The synthesis and physical properties of cyanurate networks formed from two new tricyanate monomers, 1,3,5-tris[(4-cyanatophenylmethyl]benzene and 3,5-bis[(4-cyanatophenylmethyl)]phenylcyanate, are reported and compared to those of 1,1,1-tris[(4-cyanatoph

5-Substituted isophthalate-based organic electrochromic materials

A new series of isophthalate-based electrochromic materials were prepared. The functional groups at the 5-position of isophthalate have a significant influence on the observed color. In particular, an electrochemically active nitro group induced a multi-color display, indicating that further electrochromic properties could be manipulated using more diverse 5-substituted isophthalate derivatives. The Royal Society of Chemistry 2008.

4-substituted-phenyl(bisoxazoline)-rhodium complexes: Efficiency in the catalytic asymmetric reductive aldol reaction

Electronic effects of the substituents on the phenyl ring of the phenyl(bisoxazoline) ligand skeleton of rhodium catalysts was examined in the asymmetric reductive aldol reactions of acrylates and aldehydes. The electron-withdrawing NO2 group o

DABCO-directed self-assembly of bisporphyrins (DABCO = 1,4-diazabicyclo[2. 2.2]octane)

Three isomeric zinc bisporphyrins have been prepared by covalently linking together two aminoporphyrins with an isophthalic acid derivative. The porphyrins differ in the substitution pattern on the meso phenyl groups, that is, ortho, meta, or para. Titrations carried out by UV-visible and 1H NMR spectroscopy have been used to map out the stabilities and the stoichiometries of the complexes formed with 1,4-diazabicyclo[2.2.2]octane (DABCO) in chloroform. The ortho-and meta-substituted bisporphyrins form 1:1 intramolecular sandwich complexes. The para-substituted bisporphyrin cannot adopt the cofacial conformation required for this type of complex and forms a higher order 2:2 intermolecular assembly, which is stable over a wide range of DABCO concentrations.

Cyclic anhydrides formed from 1,12-dimethylbenzo[c]phenanthrene-5,8- dicarboxylic acid and 1,3-benzenedicarboxylic acids

Optically active 1,12-dimethylbenzo[c]phenanthrene-5,8-dicarboxylic acid and 1,3-benzenedicarboxylic acids were converted to cyclic anhydrides with trimeric and/or tetrameric structure.