352272-77-6Relevant academic research and scientific papers
Synthesis of enantiopure N-protected 4,5-disubstituted 3-pyrrolidinones and N-protected 2,5-disubstituted 3-pyrrolidinones via the Dieckmann reaction of dicarbonyl compounds derived from enantiopure β-amino esters
Wang, Yue,Ma, Dawei
, p. 725 - 730 (2001)
Under the action of KHMDS in THF solvent the Dieckmann reaction of dicarbonyl compounds derived from enantiopure β-amino esters provides enantiopure N-protected 4,5-disubstituted 3-pyrrolidinones, whereas N-protected 2,5-disubstituted 3-pyrrolidinones formed in reactions mediated by tert-BuOK in DMF or toluene. Reduction of these pyrrolidinones afforded enantiopure polysubstituted pyrrolidines.
