352288-41-6

Upstream product

• 56990-02-4 3,5-dibromobenzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 352288-51-8 3-(3,5-dibromophenyl)prop-2-en-1-ol 
• 352287-49-1 C₂₂H₂₄Br₂O₄ 
• 1304683-91-7 (2R,3S)-tert-butyl-3-(3,5-dibromophenyl)-2-(4-bromophenyl)-2-cyanopent-4-enoate 
• 1304683-86-0 (2S,3S)-tert-butyl 3-(3,5-dibromophenyl)-2-cyano-2-ethylpent-4-enoate 
• 1304683-97-3 3,5-dibromocinnamyl methyl carbonate 
• 937795-38-5 C₄₀H₃₂O₂ 
• 937795-37-4 C₃₄H₂₈O₂ 
• 937795-39-6 C₂₆H₁₆F₁₂O₂ 
• 937795-35-2 C₂₂H₂₀O₂ 
• 937795-34-1 BrC₆H₄C₃H₅O₂C₇H₆C₆H₄C₆H₃Br 
• 937795-33-0 C₂₂H₁₈Br₂O₂ 
• 937795-32-9 C₁₀H₁₀Br₂O₂C₆H₄ 
• 937795-31-8 C₁₀H₁₀Br₂O₂ 
• 937795-30-7 (3,5-dibromophenyl)glycidol 

Relevant academic research and scientific papers

A highly enantio- and diastereoselective molybdenum-catalyzed asymmetric allylic alkylation of cyanoesters

An efficient molybdenum-catalyzed asymmetric allylic alkylation (Mo-AAA) of cyanoester nucleophiles is reported. A number of highly functionalized branched cyanoesters containing a quaternary carbon stereocenter with a vicinal tertiary stereocenter are obtained. This method generates a number of functionalized cyanoesters in excellent yield and chemoselectivity in good to excellent diastereoselectivity and enantioselectivity.

Design of potent PPARα agonists

Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARα agonists. Optimum PPARα potency and selectivity were obtained with substituents having van der Waals volume around 260. Compound 6 had a PPARα potency of 0.002 μM and a selectivity ratio to PPARγ and PPARδ of 410 and 2000, respectively.

Suzuki cross-coupling on enantiomerically pure epoxides: Efficient synthesis of diverse, modular amino alcohols from single enantiopure precursors

(Chemical Equation Presented) Suzuki arylation of enantiopure (4-bromophenyl)- or (3,5-dibromophenyl)glycidyl ethers has been achieved in toluene under Buchwald conditions [ArB(OH)2 (1.1 equiv), Cs 2CO3 (2 equiv), Pd2(dba)3· C6H6 (1 mol %), S-Phos (4 mol %), toluene, 100°C] allowing for the formation of modular arylglycidyl ethers not directly available in enantiopure form by epoxidation routes. These bulky ethers, when submitted to regioselective and stereospecific ring opening with ammonia [aq NH 3, LiClO4 (1 equiv), THF, microwave irradiation (80 W), 125°C] in a sealed tube, provide access to novel enantiopure β-amino alcohols which, in turn, provide an easy access to structurally complex C 2 symmetrical bisoxazolines.

Compounds, their preparation and use

The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).