352348-63-1Relevant academic research and scientific papers
Synthesis, spectroscopic, crystal structure and in vitro cytotoxicity studies of N-thiophenoyl-N′-substituted phenyl thiocarbamide derivatives
Pandey, Sunil K.,Pratap, Seema,Marverti, Gaetano,Kaur, Manpreet,Jasinski, Jerry P.
, p. 447 - 454 (2019/01/05)
A series of eight biologically active N, N′-disubstituted thiocarbamide compounds (1–8) have been prepared from thiophene-2-carbonyl isothiocyanate and various substituted aromatic primary amines (2,4-dichlorophenyl aniline, 4-chloro-3-nitrophenyl aniline
Synthesis and characterization of some new thioureides of 2-thiophenecarboxylic acid with potential pharmacological activity
Badiceanu, Carmellina Daniela,Missir, Alexandru-Vasile
experimental part, p. 27 - 31 (2010/05/19)
This paper presents our research concerning the synthesis of new thioureides from 2-thiophenecarboxylic acid, being known the remarkable pharmacological properties of some thioureea derivatives like: Antihistaminic, local anesthetic, tuberculostatic, sedative, antidepressant, anticoagulant, analgesic, antiseptic-desinfectant etc. The new compounds have potential pharmacological properties. The new compounds are prepared by reacting the 2-thenoil-isothiocyanates with different primary aromatic amines. We established the necessary reaction parameters for better yields. The compounds were characterized by their physical constants (melting points, solubility) and structurally by 1H-NMR and 13C-NMR.
