35237-01-5Relevant academic research and scientific papers
Synthesys of Single Isomers (E or Z) of Unsatured Carboxylic Acids by the Horner-Wittig Reaction
Levin, Daniel,Warren, Stuart
, p. 1799 - 1808 (2007/10/02)
Alkyl(diphenyl)phosphine oxides (5) are used to synthesize pure E or Z isomers of unsatured acids.The keto acids (10), made by two routes, are reduced to hydroxy acids whose crystalline lactones (12) can be separated and purified.Stereospecific elimination of Ph2PO2- gives the unsatured acids.
