3524-28-5

Usage

Uses

Used in Drug Development:
1-(2-CHLOROBENZYL)-1H-PYRAZOL-5-AMINE is used as a potential candidate in drug development for the treatment of various diseases and conditions. Its diverse pharmacological properties, including anti-inflammatory, analgesic, and antipyretic effects, make it a promising compound for further research and development.
Used in Medicinal Chemistry:
1-(2-CHLOROBENZYL)-1H-PYRAZOL-5-AMINE is used in medicinal chemistry to explore its full scope of pharmacological and therapeutic properties. The introduction of a chloro group in the benzyl moiety can potentially modulate the biological activity of the compound, making it a valuable tool for the development of new drugs and therapies.

InChI:InChI=1/C10H10ClN3/c11-9-4-2-1-3-8(9)7-14-10(12)5-6-13-14/h1-6H,7,12H2

Upstream product

• 30152-43-3 3-{N'-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-hydrazino}-propionitrile 

Relevant academic research and scientific papers

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

Approach to the library of fused pyridine-4-carboxylic acids by combes-type reaction of acyl pyruvates and electron-rich amino heterocycles

A library of fused pyridine-4-carboxylic acids (including pyrazolo[3,4-b]pyridines, isoxazolo[5,4-b]pyridines, furo[2,3-b]pyridines, thieno[2,3-b]pyridines, and pyrido[2,3-d]pyrimidines) was generated by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles followed by hydrolysis of the ester. The library members were also demonstrated to undergo the standard combinatorial transformations including amide coupling and esterification, as well as less common heterocyclizations to 1,2,4-triazoles and 1,2,4-oxadiazoles.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.