352431-37-9

Usage

Uses

Used in Research and Development:
L-2-AMINOBUTYRIC-3,3-D2 ACID is used as a research compound for studying the biochemical and biophysical properties of L-2-aminobutyric acid and its interactions with other molecules. The deuterium labeling allows for the differentiation between the labeled and unlabeled compounds, which can be crucial in understanding the mechanisms of action and the role of L-2-aminobutyric acid in various biological processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, L-2-AMINOBUTYRIC-3,3-D2 ACID is used as a starting material or an intermediate in the synthesis of isotopically labeled drugs and drug candidates. The incorporation of deuterium into the molecule can potentially improve the stability, solubility, and pharmacokinetic properties of the final drug product, leading to enhanced therapeutic effects and reduced side effects.
Used in Analytical Chemistry:
L-2-AMINOBUTYRIC-3,3-D2 ACID is employed as an internal standard or a reference compound in analytical chemistry, particularly in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. The deuterium labeling provides a distinct signature for the compound, which can be used to accurately quantify and identify the native L-2-aminobutyric acid in complex biological samples.
Used in Neuropharmacology:
In the field of neuropharmacology, L-2-AMINOBUTYRIC-3,3-D2 ACID is used as a research tool to investigate the role of L-2-aminobutyric acid in the central nervous system. The deuterium-labeled compound can help researchers understand the mechanisms of neurotransmission, synaptic plasticity, and the potential therapeutic applications of L-2-aminobutyric acid in the treatment of neurological disorders.
Used in Metabolic Studies:
L-2-AMINOBUTYRIC-3,3-D2 ACID is utilized in metabolic studies to trace the metabolic pathways and enzyme interactions involving L-2-aminobutyric acid. The deuterium labeling can provide insights into the metabolic fate of the compound and its role in various metabolic processes, which can be valuable for the development of novel therapeutic strategies targeting L-2-aminobutyric acid metabolism.

Upstream product

• 1246820-39-2 C₁₁H₁₄⁽²⁾H₅NO₅ 
• 73377-67-0 3-Phenyl-5-<1'-13C,1'-D2>ethylhydantoin 

Relevant academic research and scientific papers

Pyrrolizidine alkaloid biosynthesis. Incorporation of 2-aminobutanoic acid labelled with 13C or 2H into the senecic acid portion of rosmarinine and senecionine

(±)-[3,4-13C2]-2-Aminobutanoic acid 10 and (±)-[3,4-2H5]-2-aminobutanoic acid 11 are synthesized by alkylating diethyl acetamidomalonate with labelled ethyl iodide followed by acid hydrolysis. These compounds are used to obtain complete labelling patterns for the first time in a necic acid by studying the pyrrolizidine alkaloids rosmarinine 3 and senecionine 1 using NMR spectroscopy. The senecic acid portion 12 of both alkaloids shows equal incorporation of [3,4-13C2]-2-aminobutanoic acid 10 into the two C5 halves of the C10 acid consistent with formation of senecic acid via two molecules of isoleucine. After feeding [3,4-2H5]-2-aminobutanoic acid 11, retention of 2H at C-13 and C-20 of both alkaloids 13 confirms that the biosynthesis does not involve keto intermediates at these carbon atoms.

Mechanism of α-Hydroxy-α-Amino Acid Formation in the Biosynthesis of Peptide Ergot Alkaloids

(R,S)-2-Aminobutyric acid was synthesized and fed to cultures of Claviceps purpurea.Mass spectral analysis of the resulting peptide ergot alkaloid ergostine (IIb) showed the presence of (13)C as well as two atoms of deuterium, ruling out a 2