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352432-46-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 352432-46-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,2,4,3 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 352432-46:
123 % 10 = 3
So 352432-46-3 is a valid CAS Registry Number.

352432-46-3Relevant articles and documents

New Disaccharide-Based Ether Lipids as SK3 Ion Channel Inhibitors

Berthe, Wilfried,Sevrain, Charlotte M.,Chant?me, Aurélie,Bouchet, Ana Maria,Gueguinou, Maxime,Fourbon, Yann,Potier-Cartereau, Marie,Haelters, Jean-Pierre,Couthon-Gourvès, Hélène,Vandier, Christophe,Jaffrès, Paul-Alain

, p. 1531 - 1539 (2016)

The SK3 potassium channel is involved in the development of bone metastasis and in the settlement of cancer cells in Ca2+-rich environments. Ohmline, which is a lactose-based glycero-ether lipid, is a lead compound that decreases SK3 channel activity and consequently limits the migration of SK3-expressing cells. Herein we report the synthesis of three new ohmline analogues in which the connection of the disaccharide moieties (1→6 versus 1→4) and the stereochemistry of the glycosyl linkage was studied. Compound 2 [3-(hexadecyloxy)-2-methoxypropyl-6-O-α-d-glucopyranosyl-β-d-galactopyranoside], which possesses an α-glucopyranosyl-(1→6)-β-galactopyranosyl moiety, was found to decrease SK3 current amplitude (70 % inhibition at 10 μm), displace SK3 protein outside caveolae, and decrease constitutive Ca2+entry (50 % inhibition at 300 nm) and SK3-dependent cell migration (30 % at 300 nm) at a level close to that of the benchmark compound ohmline. Compound 2, which decreases the activity of SK3 channel (but not SK2 channel), is a new drug candidate to reduce cancer cell migration and to prevent bone metastasis.

Synthesis and structural characterization of three unique helicobacter pylori a-cholesteryl phosphatidyl glucosides

Nguyen, Huy Q.,Davis, Ryan A.,Gervay-Hague, Jacquelyn

, p. 13400 - 13403 (2014)

Steryl glycosides produced by bacteria play important biological roles in the evasion and modulation of host immunity. Step-economical syntheses of three cholesteryl-6-Ophosphatidyl-α-d-glucopyranosides (αCPG) unique to Helicobacter pylori have been achie

Efficient Syntheses of β-Cyanosugars Using Glycosyl Iodides Derived from Per-O-silylated Mono- and Disaccharides

Bhat, Abhijit S.,Gervay-Hague, Jacquelyn

, p. 2081 - 2084 (2001)

Reported herein is a general method for the efficient syntheses of a variety of β-cyano glycosides through the activation of per-O-trimethylsilyl glycosides with TMSI to form α-glycosyl iodides, which undergo SN2-type displacement when treated with tetrabutylammonium cyanide. The cyanoglycosides were reduced under mild conditions using NaBH4 in the presence of catalytic CoCl2(H2O)6 in THF/H2O to give the corresponding aminomethyl glycosides.

Expeditious Synthesis of Ieodoglucomides A and B from the Marine-Derived Bacterium Bacillus licheniformis

Podilapu, Ananda Rao,Emmadi, Madhu,Kulkarni, Suvarn S.

, p. 3230 - 3235 (2018/07/06)

We report the total synthesis of ieodoglucomides A and B. The key steps of the synthesis are a glycosyl-iodide-mediated β-stereoselective glycosylation without neighbouring-group participation, a regioselective acylation, and a Grubbs cross-metathesis reaction. The short and efficient synthesis involves 11 steps, with 38–40 % overall yield.

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