35246-65-2

Upstream product

• 35246-64-1 7β-phenylacetamido-3-hydroxymethyl-3-cephem-4-carboxylic acid diphenylmethyl ester 
• 35246-64-1 (6R,7R)-benzhydryl 3-(hydroxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 

Downstream Products

• 36923-19-0 7β-phenylacetamido-3-cephem-4-carboxylic acid diphenylmethyl ester 
• 35246-66-3 (6R)-3-formyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 56984-16-8 (6R)-3-formyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 36923-19-0 diphenylmethyl (6R,7R)-7-(phenylacetamido)ceph-3-em-4-carboxylate 
• 58619-71-9 (6R)-3-difluoromethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 52243-56-8 (6R)-3-(hydroxyimino-methyl)-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 54493-84-4 N-((5aR)-3ξ-methoxy-1,7-dioxo-(5ar)-1,4,6,7-tetrahydro-3H,5aH-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6t-yl)-2-phenyl-acetamide 
• 94796-16-4 Diphenylmethyl (6R,7R)-3-<2-Methoxycarbonylvinyl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 135299-73-9 Diphenylmethyl (6R,7R)-3-<(E)-2-(4-Methyl-1,3-thiazol-5-yl)vinyl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 39914-42-6 (6R)-5ξ,8-dioxo-7t-(2-phenyl-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 36923-17-8 (6R,7R)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 33477-97-3 (6R,7R)-7-(phenylacetamido)ceph-3-em-4-carboxylic acid 
• 36923-21-4 diphenylmethyl 7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 52243-69-3 (6R)-3-cyano-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant academic research and scientific papers

7 β-phenylacetylamino-3-no-3-cephem-4-carboxylic acid bisphenylmethyl method for preparing methyl

The invention provides a method for preparing a 7beta-phenylacetyl amino-3-free-3-cephem-4-carboxylic acid benzyl ester from 7beta-phenylacetyl amino-3-methylol-3-cephem-4-carboxylic acid benzyl ester by adopting a catalytic oxidation and catalytic formylation two-step method. The method disclosed by the invention has the characteristics of being available in raw materials, short in reaction step, mild in reaction condition, fewer in three wastes, good in purity of a target product, high in atom economy and the like.

Process for making 3-formylcephem derivatives

The present invention is concerned with a novel process for the making of a compound of formula I STR1 by oxidizing the corresponding 3-hydroxymethyl-cephem derivative with an inorganic hypohalite or inorganic halite in the presence of compounds of formul

Oxidation of Alcohols with o-Iodobenzoic Acid (IBX) in DMSO: A New Insight into an Old Hypervalent Iodine Reagent

The ultracentennial 10-I-4 iodinane oxide IBX (3; o-iodoxybenzoic acid; 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide) represents a new oxidizing reagent that successfully joins to the large family of known oxidants.IBX, in contrast to other valuable oxidants, is inexpensive to prepare and easy to handle, can tolerate moisture and water, and generally gives very good yields.Furthermore, IBX is mild and chemoselective (primary alcohols are converted into aldehydes with no overoxidation to acids; 1,2-diols are converted to α-ketols or α-diketones without oxidative cleavage; amino alcohols are oxidized to amino carbonyls, without protection of the amino group; sensitive heterocycles are not affected; various other functional groups are compatible with IBX oxidation).IBX is versatile (it works in various solvents and it is highly sensitive to temperature variations), and its solutions in DMSO are stable enough to carry out the oxidation reaction easily.