352525-97-4

Usage

Uses

Used in Chemical Synthesis:
TRANS-2-(1-NAPHTHYL)VINYLBORONIC ACID is used as an intermediate compound for the synthesis of α-arylated/α-vinylated carbonyl compounds. Its unique structure allows for the formation of new carbon-carbon bonds, which are essential in the creation of complex organic molecules.
Used in Pharmaceutical Industry:
TRANS-2-(1-NAPHTHYL)VINYLBORONIC ACID is used as a building block for the development of novel pharmaceutical compounds. Its reactivity and structural diversity make it a valuable asset in the design and synthesis of new drugs with potential therapeutic applications.
Used in Material Science:
In the field of material science, TRANS-2-(1-NAPHTHYL)VINYLBORONIC ACID can be utilized as a component in the development of advanced materials with specific properties. Its ability to form stable bonds with other molecules can contribute to the creation of materials with enhanced performance characteristics.

Upstream product

• 15727-65-8 1-ethynylnaphthalene 
• 274-07-7 benzo[1,3,2]dioxaborole 
• 1127-76-0 1-ethylnapthelene 

Downstream Products

• 1400414-58-5 (E)-3,5-bis(4-methoxyphenyl)-4-(2-(naphthalen-4-yl)vinyl)isoxazole? 

Relevant academic research and scientific papers

Copper-catalyzed oxyvinylation of diazo compounds

A copper(I)-catalyzed vinylation of diazo compounds with vinylbenziodoxolone reagents (VBX) as partners is reported. The transformation tolerates diverse functionalities on both reagents delivering polyfunctionalized vinylated products. The strategy was successfully extended to a three-component/intermolecular version with alcohols. The obtained products contain synthetically versatile functional groups, such as an aryl iodide, an ester, and an allylic leaving group, enabling further modification.

Synthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4- hydroxyphenyl)-isoxazoles as ligands for the estrogen receptor

A series of 3,5-bis (4-hydroxyphenyl) isoxazoles bearing a styryl/alkyl vinyl group at the 4-position were prepared and evaluated as ligands for the estrogen receptor-alpha (ERα). The target compounds were prepared using the Suzuki reaction to couple an iodo-isoxazole intermediate with a series of styryl/alkenyl boronic acids, followed by O-demethylation. The products were evaluated for their estrogen receptor-α ligand binding domain (ERα-LBD) binding affinity using a competitive binding assay. The 4-(4-hydroxystyryl) derivative 4 h displays binding properties similar to those of the previously described pyrazole class of ER ligands, indicating that the ERα-LBD tolerates the presence of the added vinyl group at the 4-position of the isoxazole ring.