352540-52-4Relevant academic research and scientific papers
Furan Ring Opening – Pyridine Ring Closure: An Efficient Approach towards 6H-Isochromeno[4,3-b]pyridin-6-ones from Readily Available Furans and Phthalaldehydic Acid Methyl Esters
Shpuntov, Pavel M.,Kolodina, Alexandra A.,Uchuskin, Maxim G.,Abaev, Vladimir T.
supporting information, p. 461 - 469 (2018/02/09)
An efficient iodine-catalyzed three-component Mannich-type reaction of various 2-alkylfurans, methyl 2-formylbenzoates and carbamates under mild reaction conditions was realized. Synthetic utility of the resulting N-Boc-1-[2-(carbomethoxy)aryl]furfurylami
An Unexpected C-C Bond Cleavage of Acetophenones: Synthesis of Bis(heteroaryl)arylmethanes and Triarylmethanes via SeO2/Lanthanide Chloride Catalyzed Friedel-Crafts Arylation
Kumar, G. Santosh,Kumar, A. Sanjeeva,Swetha,Babu, B. Madhu,Meshram
supporting information, p. 631 - 639 (2016/03/12)
A novel synthesis of bisheteroarylaryl methanes and triarylmethanes is described by the selective C-C bond cleavage of acetophenones in the presence of SeO2/lanthanide chlorides. The present strategy provides an in situ generation of aldehydes from acetophenones followed by a double Friedel-Crafts reaction of electron-rich arenes. Natural product 1,1,1-tris(3-indolyl)methane is synthesized in a single step following the same protocol.
Furan ring opening - Isocoumarine ring closure: A recyclization reaction of 2-carboxyaryldifurylmethanes
Abaev, Vladimir T.,Dmitriev, Artem S.,Gutnov, Andrey V.,Podelyakin, Sergey A.,Butin, Alexander V.
, p. 1195 - 1204 (2007/10/03)
A general method for the synthesis of isocoumarine derivatives has been developed. Bis(5-R-2-furyl)methylbenzoic acids (R = methyl, ethyl) underwent recyclization and subsequent cyclization into tetracyclic isochromene-1-one derivatives under treatment with hydrogen chloride in methanol. It has been shown that intermediate 4-(5-R-furan-2-yl)-3-(3-oxo-3-R-propyl)-isochromene-1- ones can be obtained selectively by varying a concentration of the hydrogen chloride and reaction times. In the case of R = tert-butyl only corresponding 4-[5-(tert-butyl)-2-furyl]-3-(4,4-dimethyl-3-oxopentyl)-1-isochromenones were isolated regardless of the reaction conditions.
New synthesis of 3-(2-furyl)phthalides
Dmitriev,Pilipenko,Abaev,Butin
, p. 1102 - 1104 (2007/10/03)
3-(2-Furyl)phthalides were synthesized for the first time by the reaction of 2-formylbenzoic acids with furan derivatives in the presence of an acidic catalyst. It was found that the reaction of 2-formylbenzoic acids and 2-alkylfurans in aqueous dioxane i
