352545-18-7Relevant academic research and scientific papers
The ruthenium-catalyzed: Meta -selective C-H nitration of various azole ring-substituted arenes
Zhang, Dong,Gao, Di,Cai, Jinlin,Wu, Xiaoyu,Qin, Hong,Qiao, Kai,Liu, Chengkou,Fang, Zheng,Guo, Kai
, p. 9065 - 9069 (2019)
The efficient ruthenium-catalyzed meta-selective CAr-H nitration of azole ring substituted arenes has been developed. In this work, Ru3(CO)12 was used as the catalyst, AgNO2 as the nitro source, HPcy3+·BF4- as the ligand, pivalic acid as the additive, and DCE as the solvent, and a wide spectrum of arenes bearing thiazole, pyrazolyl or removable oxazoline directing groups were tolerated in this meta-selective CAr-H nitration, affording the nitrated products in moderate to good yields. Moreover, this study reveals a gentler and environmentally friendly way to access meta-nitration arenes compared to the traditional process.
