352552-18-2

Upstream product

• 328396-54-9 (1'R,2'R,3'S,4'R,5'S)-4-(chloropurin-9-yl)-1-[(phenylmethoxy)methyl]-bicyclo[3.1.0]hexane-2,3-(O-isopropylidene) 
• 328396-55-0 (1'R,2'R,3'S,4'R,5'S)-4-(6-chloropurine-9-yl)-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-(O-isopropylidene) 
• 3718-88-5 3-iodobenzylamine hydrochloride 
• 352552-16-0 (1aS,1bR,4aS,5R,5aS)-5-(6-Chloro-purin-9-yl)-3,3-dimethyl-tetrahydro-2,4-dioxa-cyclopropa[a]pentalene-1a-carboxylic acid 

Relevant academic research and scientific papers

Ring-constrained (N)-methanocarba nucleosides as adenosine receptor agonists: Independent 5′-uronamide and 2′-deoxy modifications

Novel methanocarba adenosine analogues, having the pseudo-ribose northern (N) conformation preferred at adenosine receptors (ARs), were synthesized and tested in binding assays. The 5′-uronamide modification preserved [N6-(3-iodobenzyl)] or enhanced (N6-methyl) affinity at A3ARs, while the 2′-deoxy modification reduced affinity and efficacy in a functional assay.