352557-07-4 Usage
Uses
Used in Pharmaceutical Research:
1(2H)-Isoquinolinone, 6-hydrazinyl-3,4-dihydrois utilized as a key compound in pharmaceutical research, particularly for its potential biological activities. It serves as a valuable starting material for the synthesis of various drug candidates due to its unique chemical structure and properties.
Used in Organic Synthesis:
In the field of organic synthesis, 1(2H)-Isoquinolinone, 6-hydrazinyl-3,4-dihydrois used as an intermediate or building block for the creation of more complex molecules. Its unique structure allows for further functionalization and modification, making it a versatile component in the synthesis of various organic compounds.
Used in Antitumor Applications:
1(2H)-Isoquinolinone, 6-hydrazinyl-3,4-dihydrohas demonstrated potential antitumor properties, making it a candidate for further research and development as a therapeutic agent against cancer. Its hydrazine group and dihydro structure may contribute to its biological activity, and further studies are needed to explore its full potential in this application.
Used in Antibacterial Applications:
1(2H)-Isoquinolinone, 6-hydrazinyl-3,4-dihydroalso exhibits antibacterial properties, which can be harnessed for the development of new antibiotics or as additives in various industries to prevent bacterial growth and contamination.
Used in Drug Development:
As a building block in drug development, 1(2H)-Isoquinolinone, 6-hydrazinyl-3,4-dihydrocan be used to create novel drug candidates with improved pharmacological profiles. Its unique structure and potential biological activities make it an attractive candidate for the development of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 352557-07-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,2,5,5 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 352557-07:
(8*3)+(7*5)+(6*2)+(5*5)+(4*5)+(3*7)+(2*0)+(1*7)=144
144 % 10 = 4
So 352557-07-4 is a valid CAS Registry Number.
352557-07-4Relevant articles and documents
Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors
Branca, Danila,Cerretani, Mauro,Jones, Philip,Koch, Uwe,Orvieto, Federica,Palumbi, Maria Cecilia,Rowley, Michael,Toniatti, Carlo,Muraglia, Ester
body text, p. 4042 - 4045 (2010/03/05)
PARP inhibitors have been demonstrated to retard intracellular DNA repair and therefore sensitize tumor cells to cytotoxic agents or ionizing radiation. We report the identification of a novel class of PARP1 inhibitors, containing a pyrrolo moiety fused to a dihydroisoquinolinone, derived from virtual screening of the proprietary collection. SAR exploration around the nitrogen of the aminoethyl appendage chain of 1 led to compounds that displayed low nanomolar activity in a PARP1 enzymatic assay.
FUSED INDOLES AND INDAZOLES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
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Page/Page column 44, (2010/11/30)
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP- ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion
Pyrrolo-isoquinoline and tetra-hydropyrrolo-isoquinoline derivatives and their use as mediators of the 5-HT7 receptor
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, (2008/06/13)
Compounds of the formula are useful in the treatment of anxiety, depression and related disorders of the central nervous system and other conditions such as schizophrenia, sleep disorders, including instances of circadian rhythm, the treatment of alcohol
