352563-40-7Relevant academic research and scientific papers
5-Amino-2-aryl-1,2,3-triazol-4-carboxylic acids: Synthesis, photophysical properties, and application prospects
Safronov, Nikita E.,Fomin, Timur O.,Minin, Artem S.,Todorov, Lozan,Kostova, Irena,Benassi, Enrico,Belskaya, Nataliya P.
, (2020/03/30)
To enlarge the highly active fluorophore family of small molecular heterocycles, we present an effective strategy for the synthesis of novel 2-aryl-1,2,3-triazol-4-carboxylic acids (ATAs). The behavior of ATAs in different solvents showed that these new 1
2-Aryl-5-amino-1,2,3-triazoles: New effective blue-emitting fluorophores
Gavlik, Kseniya D.,Sukhorukova, Ekaterina S.,Shafran, Yuri M.,Slepukhin, Pavel A.,Benassi, Enrico,Belskaya, Nataliya P.
, p. 229 - 242 (2016/09/02)
The synthesis of a new series of 2-aryl-5-amino-1,2,3-triazole derivatives is reported. The photochemical properties of these new fluorophores were studied both experimentally and using theoretical models. The compounds were found to be fluorescent, with
Multistep flow synthesis of 5-amino-2-aryl-2h-[1,2,3]-triazole-4-carbonitriles
Jacq, Jér?me,Pasau, Patrick
, p. 12223 - 12233 (2015/03/31)
1,2,3-Triazole has become one of the most important heterocycles in contemporary medicinal chemistry. The development of the copper-catalyzed Huisgen cycloaddition has allowed the efficient synthesis of 1-substituted 1,2,3-triazoles. However, only a few methods are available for the selective preparation of 2-substituted 1,2,3-triazole isomers. In this context, we decided to develop an efficient flow synthesis for the preparation of various 2-aryl-1,2,3-triazoles. Our strategy involves a three-step synthesis under continuous-flow conditions that starts from the diazotization of anilines and subsequent reaction with malononitrile, followed by nucleophilic addition of amines, and finally employs a catalytic copper(II) cyclization. Potential safety hazards associated with the formation of reactive diazonium species have been addressed by inline quenching. The use of flow equipment allows reliable scale up processes with precise control of the reaction conditions. Synthesis of 2-substituted 1,2,3-triazoles has been achieved in good yields with excellent selectivities, thus providing a wide range of 1,2,3-triazoles.
