35260-96-9

Basic information

• Product Name: 2-(1-ETHOXYPROPYLIDENE)MALONONITRILE
• Synonyms: 2-(1-ETHOXYPROPYLIDENE)MALONONITRILE;alpha-Cyano-beta-ethyl-beta-ethoxyacrylonitrile;NSC 27796;(1-Ethoxypropylidene)malononitrile
• CAS NO: 35260-96-9
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Mol File: 35260-96-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 322.2°C at 760 mmHg
• Flash Point: 138.3°C
• Appearance: /
• Density: 1.022g/cm³
• Vapor Pressure: 0.000285mmHg at 25°C
• Refractive Index: 1.462
• CAS DataBase Reference: 2-(1-ETHOXYPROPYLIDENE)MALONONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-ETHOXYPROPYLIDENE)MALONONITRILE(35260-96-9)
• EPA Substance Registry System: 2-(1-ETHOXYPROPYLIDENE)MALONONITRILE(35260-96-9)

Safety Data

• Hazardous Substances Data: 35260-96-9(Hazardous Substances Data)

Usage

General Description

2-(1-Ethoxypropylidene)malononitrile is a chemical compound with the molecular formula C9H13NO2. It is a clear, colorless liquid that is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2-(1-ETHOXYPROPYLIDENE)MALONONITRILE is known for its high reactivity and is often used in the preparation of various organic compounds due to its ability to undergo multiple chemical reactions. It is also used as a building block in the production of complex organic molecules, making it a valuable compound in the field of organic synthesis. Additionally, 2-(1-Ethoxypropylidene)malononitrile is used as a reagent in the preparation of various heterocyclic compounds and is an important tool in the field of medicinal chemistry.

InChI:InChI=1/C8H10N2O/c1-3-8(11-4-2)7(5-9)6-10/h3-4H2,1-2H3

Upstream product

• 109-77-3 malononitrile 
• 115-80-0 Triethyl orthopropionate 

Downstream Products

• 35261-00-8 5-amino-3-ethyl-isoxazole-4-carbonitrile 
• 650628-98-1 5-amino-3-ethyl-1-(3-methoxyphenyl)-1H-pyrazole-4-carbonitrile 
• 1298095-83-6 3-ethyl-1-tosyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dithione 
• 1298095-86-9 5-ethyl-2-(4-methoxyphenyl)-7-phenyl-2-thioxo-1,2,3,7-tetrahydropyrazolo[3,4-d][1,3,2]diazaphosphinine-4-thione 
• 1298095-89-2 5-ethyl-2-(4-methoxyphenyl)-7-tosyl-2-thioxo-1,2,3,7-tetrahydropyrazolo[3,4-d]-[1,3,2]diazaphosphinine-4-thione 
• 1298095-80-3 3-ethyl-1-phenyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dithione 
• 50427-83-3 5-amino-3-ethyl-1-phenyl-1H-pyrazolo-4-carbonitrile 
• 1298095-78-9 5-amino-3-ethyl-1-tosyl-1H-pyrazolo-4-carbonitrile 
• 1607025-19-3 5-(4-chloro-3-methoxyphenyl)-2-ethyl-7-oxo-4H,7H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1607025-20-6 5-(4-chloro-3-methoxyphenyl)-2-ethyl-7-oxo-4H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1607025-21-7 (E)-5-(4-chloro-3-methoxyphenyl)-N-(1-(dimethylamino)ethylidene)-2-ethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1607023-70-0 5-(4-chloro-3-methoxyphenyl)-2-ethyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)-4H,7H-pyrazolo[1,5-a]pyrimidin-7-one 
• 870189-49-4 2-[5-ethyl-2-(2-methoxy-phenyl)-4-thiocarbamoyl-2H-pyrazol-3-ylamino]-5-methoxy-benzoic acid methyl ester 
• 870189-43-8 2-[5-ethyl-2-(2-methoxy-phenyl)-4-thiocarbamoyl-2H-pyrazol-3-ylamino]-5-methyl-benzoic acid methyl ester 

Relevant articles and documents

Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors

Herein we report the discovery of a series of new small molecule inhibitors of histone lysine demethylase 4D (KDM4D). Molecular docking was first performed to screen for new KDM4D inhibitors from various chemical databases. Two hit compounds were retrieved. Further structural optimization and structure-activity relationship (SAR) analysis were carried out to the more selective one, compound 2, which led to the discovery of several new KDM4D inhibitors. Among them, compound 10r is the most potent one with an IC50 value of 0.41?±?0.03?μM against KDM4D. Overall, compound 10r could be taken as a good lead compound for further studies.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS

The invention provides a compound of formula (I) wherein G is a pyrazole ring as defined in the specification and R4, R5, R6 and R7 are as defined in the specification; or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity.