352655-19-7Relevant academic research and scientific papers
Synthesis of chiral monoaza-15-crown-5 ethers from a chiral amino alcohol and enantiomeric recognition of potassium and sodium salts of amino acids
Togrul, Mahmut,Askin, Muzaffer,Hosgoren, Halil
, p. 2771 - 2777 (2005)
The enantiomeric recognition of chiral monoaza-crown ethers for amino acids as their sodium and potassium salts has been investigated by UV-vis. The highest discrimination was observed for TrpK (d/l = 6.47). The reversed enantioselectivity of chiral monoaza-crown ether II was observed for TrpK.
Asymmetric transfer hydrogenation of acetophenone derivatives with novel chiral phosphinite based η6-p-cymene/ruthenium(II) catalysts
Aydemir, Murat,Meric, Nermin,Baysal, Akin,Turgut, Yilmaz,Kayan, Cezmi,?eker, Sevil,To?rul, Mahmut,Gümgüm, Bahattin
experimental part, p. 1541 - 1546 (2011/06/17)
Enantioselective reduction of prochiral ketones to optically active secondary alcohols is an important subject in synthetic organic chemistry because the resulting chiral alcohols are extremely useful, biologically active compounds. The new chiral ligands (2R)-2-[benzyl{(2-((diphenylphosphanyl)oxy) ethyl)}amino]butyldiphenylphosphinite, 1 and (2R)-2-[benzyl{(2- ((dicyclohexylphosphanyl)oxy)ethyl)}amino]butyldicyclohexylphosphinite, 2 and the corresponding ruthenium(II) complexes 3 and 4 have been prepared. The structures of these complexes have been elucidated by a combination of multinuclear NMR spectroscopy, IR spectroscopy and elemental analysis. 31P-{1H} NMR, DEPT, 1H-13C HETCOR or 1H-1H COSY correlation experiments were used to confirm the spectral assignments. These ruthenium(II)-phosphinite complexes have been used as catalysts for the asymmetric transfer hydrogenation of acetophenone derivatives. Under optimized conditions, aromatic ketones were reduced in good conversions and in moderate to good enantioselectivities (up to 85% ee).
