35274-15-8

Basic information

• Product Name: N-(2-methylphenyl)ethanethioamide
• CAS NO: 35274-15-8
• Molecular Formula: C₉H₁₁NS
• Molecular Weight: 165.2553
• Mol File: 35274-15-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 238.4°C at 760 mmHg
• Flash Point: 98°C
• Density: 1.126g/cm³
• Vapor Pressure: 0.0424mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: N-(2-methylphenyl)ethanethioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methylphenyl)ethanethioamide(35274-15-8)
• EPA Substance Registry System: N-(2-methylphenyl)ethanethioamide(35274-15-8)

Safety Data

• Hazardous Substances Data: 35274-15-8(Hazardous Substances Data)

Upstream product

• 120-66-1 N-(2-methylphenyl)acetamide 
• 62-55-5 thioacetamide 
• 95-53-4 o-toluidine 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 614-69-7 2-tolyl isothiocyanate 

Downstream Products

• 120-66-1 N-(2-methylphenyl)acetamide 
• 112991-36-3 3-ethyl-2-(4-dimethylamino-styryl)-4-methyl-benzothiazolium; iodide 
• 7252-80-4 N,N'-di-o-tolylacetamidine 
• 5262-63-5 2,4-dimethyl-1,3-benzothiazole 

Relevant articles and documents

In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M

Photoswitchable reagents are powerful tools for high-precision studies in cell biology. When these reagents are globally administered yet locally photoactivated in two-dimensional (2D) cell cultures, they can exert micron- and millisecond-scale biological control. This gives them great potential for use in biologically more relevant three-dimensional (3D) models and in vivo, particularly for studying systems with inherent spatiotemporal complexity, such as the cytoskeleton. However, due to a combination of photoswitch isomerization under typical imaging conditions, metabolic liabilities, and insufficient water solubility at effective concentrations, the in vivo potential of photoswitchable reagents addressing cytosolic protein targets remains largely unrealized. Here, we optimized the potency and solubility of metabolically stable, druglike colchicinoid microtubule inhibitors based on the styrylbenzothiazole (SBT) scaffold that are nonresponsive to typical fluorescent protein imaging wavelengths and so enable multichannel imaging studies. We applied these reagents both to 3D organoids and tissue explants and to classic model organisms (zebrafish, clawed frog) in one- and two-protein imaging experiments, in which spatiotemporally localized illuminations allowed them to photocontrol microtubule dynamics, network architecture, and microtubule-dependent processes in vivo with cellular precision and second-level resolution. These nanomolar, in vivo capable photoswitchable reagents should open up new dimensions for high-precision cytoskeleton research in cargo transport, cell motility, cell division, and development. More broadly, their design can also inspire similarly capable optical reagents for a range of cytosolic protein targets, thus bringing in vivo photopharmacology one step closer to general realization.

ANTI-CANCER COMPOUNDS

Provided are methods and compositions for the treatment of diseases such as cancer. In certain aspects, compounds which can inhibit Skp2 are provided. Specifically chromenone derivatives are disclosed that have the capability toward reducing differentiation of pluripotent, multipotent or totipotent cells and thus have therapeutic utility in the treatment of a proliferative disease such as cancer.

Transamidation of thioacetamide catalyzed by SbCl3

A transamidation reaction of thioacetamide with primary and secondary amines is described. The use of catalytic amounts of SbCl3 notably increases the yields and diminishes the reaction times. Typically, the amines should be aliphatic, but aromatic amines can be used as well, though with lower yields. This is one of the few examples where antimony has been used as a catalyst in organic reactions.