35280-53-6

Usage

Uses

Used in Organic Synthesis:
2-hydroxyethyl chloroacetate is used as an intermediate in organic synthesis for its ability to participate in a variety of chemical reactions, facilitating the creation of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-hydroxyethyl chloroacetate is used as a building block for the development of new drugs, leveraging its reactivity to form essential components of medicinal compounds.
Used in Agrochemical Production:
2-hydroxyethyl chloroacetate is utilized in the production of agrochemicals, contributing to the synthesis of pesticides and other agricultural chemicals that are vital for crop protection and yield enhancement.
Used in Specialty Chemicals:
2-hydroxyethyl chloroacetate is also used in the creation of specialty chemicals, where its unique properties allow for the development of niche products tailored for specific industrial applications.

Upstream product

• 2568-30-1 2-chloromethyl-1,3-dioxolane 
• 4362-41-8 2-(chloromethylene)-1,3-dioxolane 
• 136023-39-7 cis-3,5-Dichlor-3,5-bis(chlormethyl)-1,2,4-trioxolan 
• 107-21-1 ethylene glycol 
• 79-11-8 chloroacetic acid 

Downstream Products

• 38383-43-6 2,4-dichlorophenoxy acetic acid ethylene glycol 

Relevant academic research and scientific papers

A method for preparing 2, 4 - dichlorophenoxyacetic acid (by machine translation)

The invention provides a 2, 4 - dichlorophenoxyacetic acid preparation method, comprises the following steps, first the polyol and a halogenated acetic acid to carry out the esterification reaction, to obtain halogenated acetate; then the above-mentioned step to obtain the halo acetate with 2, 4 - dichlorophen salt, to obtain 2, 4 - dichlorophenoxy ester; finally in the composite under the action of catalyst, obtained by the above-mentioned step 2, 4 - dichlorophenoxy ester hydrolytic reaction, to obtain 2, 4 - dichloro acid and polyol; the polyol C atoms is greater than or equal to 2 polyol. The invention adjusts the process route, from creative improvement on the basis of, the preparation method, the process is simple, mild condition, hydrolysis few by-products, the product has high purity, the conversion and yield higher, and intermediate halogenated acetate stable, suitable for large-scale industrial production. (by machine translation)

Functionalized ozonides by substitution reactions of chlorinated ozonides with difunctional alcohols

Substitution of 3-chloro-3,5-bis(chloromethyl)-5-methyl-1,2,4-trioxolane (3) with allyl alcohol gave the corresponding diastereomeric allyloxy-substituted ozonides 4, which were converted into diozonides 7 by ozone treatment. Substitutions of 3 with ethanediol or with 1,3-propanediol gave the corresponding hydroxyalkoxy-substituted ozonides 8, 14, which were oxidized to the corresponding aldehydes 10, 16. Reaction of 3,5-dichloro-3,5-bis(chloromethyl)-1,2,4-trioxolane (1a) with ethanediol gave the corresponding bis(hydroxy)-substituted ozonide 19 as well as a bicyclic ozonide 18 by reaction of 1a with ethanediol in a ratio of 1:1. Wiley-VCH Verlag GmbH, 1997.

TETRAHEDRAL INTERMEDIATES 4. THE EFFECT OF CHLORO-SUBSTITUENTS ON THE KINETICS OF THE BREAKDOWN OF HEMIORTHOESTERS

2-Hydroxy-2-chloromethyl-1,3-dioxolane (4) and 2-hydroxy-2-dichloromethyl-1,3-dioxolane (5) have been detected as intermediates by 1H NMR spectroscopy in the hydration of respectively 2-chloromethylene-1,3-dioxolane and 2-dichloromethylene-1,3-dioxolane in aqueous acetonitrile.The kinetics of the breakdown of (4) and (5) into ethylene glycol monochloroacetate and monodichloroacetate have been studied by uv spectroscopy and values of kH(+), kHO(-), and kH2O evaluated.It was found that the introduction of chlorosubstituents into 2-hydroxy-2-methyl-1,3-dioxolane caused a decrease in kH(+) and increase in kHO(-) and little change in kH2O for its breakdown.The mechanisms of these reactions are discussed.

The mechanism of oxidation of acetals by ozone. I. Stoichiometry, order of reaction, solvent effects, and substituent effects

A systematic investigation of the reaction between ozone and acetals to form acetal hydrotrioxides A has been undertaken.The stoichiometry of the reaction has been shown to be 1:1 in each reactant and the order of the reaction was also one in each reactant.Substituent effects measured in a variety of systems and under several conditions of temperature and solvent were found to be small (ρ=-1.10 to -1.58).Solvent polarity was also found to have little effect on the rate of the reaction.Mechanistically, these facts are interpreted in terms of a 1,3-dipolar insertion of ozone into the C-H bond of the acetal function.