35280-53-6

Basic information

• Product Name: 2-hydroxyethyl chloroacetate
• Synonyms: 2-Hydroxyethyl chloroacetate
• CAS NO: 35280-53-6
• Molecular Formula: C₄H₇ClO₃
• Molecular Weight: 138.5496
• EINECS: 252-485-5
• Mol File: 35280-53-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 246.9°C at 760 mmHg
• Flash Point: 103.1°C
• Density: 1.295g/cm³
• Vapor Pressure: 0.00435mmHg at 25°C
• Refractive Index: 1.45
• CAS DataBase Reference: 2-hydroxyethyl chloroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxyethyl chloroacetate(35280-53-6)
• EPA Substance Registry System: 2-hydroxyethyl chloroacetate(35280-53-6)

Safety Data

• Hazardous Substances Data: 35280-53-6(Hazardous Substances Data)

Usage

General Description

2-hydroxyethyl chloroacetate is a chemical compound that is composed of a chloroacetic acid molecule with an additional hydroxyethyl group attached to its carbon atom. It is commonly used as an intermediate in organic synthesis and as a building block for the production of pharmaceuticals, agrochemicals, and other specialty chemicals. 2-hydroxyethyl chloroacetate is known for its reactivity as an alkylating agent and its ability to undergo a variety of chemical reactions, including esterification, amidation, and nucleophilic substitution. Its structure and properties make it a versatile compound with a range of potential industrial applications. However, it is also important to handle this chemical with care due to its potential hazards, including its toxic and irritant properties.

Upstream product

• 136023-39-7 cis-3,5-Dichlor-3,5-bis(chlormethyl)-1,2,4-trioxolan 
• 107-21-1 ethylene glycol 
• 79-11-8 chloroacetic acid 
• 4362-41-8 2-(chloromethylene)-1,3-dioxolane 
• 2568-30-1 2-chloromethyl-1,3-dioxolane 

Downstream Products

• 38383-43-6 2,4-dichlorophenoxy acetic acid ethylene glycol 

Relevant articles and documents

A method for preparing 2, 4 - dichlorophenoxyacetic acid (by machine translation)

The invention provides a 2, 4 - dichlorophenoxyacetic acid preparation method, comprises the following steps, first the polyol and a halogenated acetic acid to carry out the esterification reaction, to obtain halogenated acetate; then the above-mentioned step to obtain the halo acetate with 2, 4 - dichlorophen salt, to obtain 2, 4 - dichlorophenoxy ester; finally in the composite under the action of catalyst, obtained by the above-mentioned step 2, 4 - dichlorophenoxy ester hydrolytic reaction, to obtain 2, 4 - dichloro acid and polyol; the polyol C atoms is greater than or equal to 2 polyol. The invention adjusts the process route, from creative improvement on the basis of, the preparation method, the process is simple, mild condition, hydrolysis few by-products, the product has high purity, the conversion and yield higher, and intermediate halogenated acetate stable, suitable for large-scale industrial production. (by machine translation)

TETRAHEDRAL INTERMEDIATES 4. THE EFFECT OF CHLORO-SUBSTITUENTS ON THE KINETICS OF THE BREAKDOWN OF HEMIORTHOESTERS

2-Hydroxy-2-chloromethyl-1,3-dioxolane (4) and 2-hydroxy-2-dichloromethyl-1,3-dioxolane (5) have been detected as intermediates by 1H NMR spectroscopy in the hydration of respectively 2-chloromethylene-1,3-dioxolane and 2-dichloromethylene-1,3-dioxolane in aqueous acetonitrile.The kinetics of the breakdown of (4) and (5) into ethylene glycol monochloroacetate and monodichloroacetate have been studied by uv spectroscopy and values of kH(+), kHO(-), and kH2O evaluated.It was found that the introduction of chlorosubstituents into 2-hydroxy-2-methyl-1,3-dioxolane caused a decrease in kH(+) and increase in kHO(-) and little change in kH2O for its breakdown.The mechanisms of these reactions are discussed.