35291-92-0

Upstream product

• 79822-46-1 4-(1,1-dimethylethyl)-3-(methoxy)benzoic acid 

Downstream Products

• 687636-13-1 2-(1,1-dimethylethyl) 4-methyl (2S,4S,5R)-1-{[4-(1,1-dimethylethyl)-3-(methoxy)phenyl]carbonyl}-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-2,4-pyrrolidinedicarboxylate 
• 927436-31-5 (2S,4S,5R)-4-(aminocarbonyl)-1-(3-methoxy-4-tert-butylbenzoyl)-2-isobutyl-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 863329-79-7 1-[(3-methoxy-4-tert-butylphenyl)carbonyl]-piperazine-2,4-dicarboxylic acid 2-methyl ester 4-tert-butyl ester 
• 1095714-03-6 C₃₈H₄₃FN₄O₈S 
• 1187384-66-2 C₂₇H₃₄N₄O₅S 

Relevant academic research and scientific papers

Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position

GSK3082 – a hepatitis C virus RNA polymerase inhibitor – and a series of analogues with structural diversity at the 5-position were prepared from a 2,2,4,5-tetrasubstituted pyrrolidine obtained with a well-defined stereochemistry from the 1,3-dipolar cycl

ANTI-INFECTIVE PYRROLIDINE DERIVATIVES AND ANALOGS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention

4-SUBSTITUTED PYRROLIDINE AS ANTI-INFECTIVES

The present invention discloses compounds of Formulae (I) and (II), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present

SUBSTITUTED HETEROCYCLES AS ANTI-INFECTIVES

The present invention discloses compounds of Formulae (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing viruses, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invent

Asymmetric synthesis of an N-acylpyrrolidine for inhibition of HCV polymerase

(Chemical Equation Presented) A practical asymmetric synthesis of a highly substituted N-acylpyrrolidine on multi-kilogram scale is described. The key step in the construction of the three stereocenters is a [3+2] cycloaddition of methyl acrylate and an i

4-ACYL-PIPERAZINES AS ANTI-VIRAL AGENTS

Anti-viral agents of Formula (I) wherein: A represents hydroxy or -NH2; D represents aryl or heteroaryl; E represents hydrogen, straight or branched chain C1-6alkyl, -CO2R1, -C(O)R1a, -C(O)NR2/s