35299-05-9Relevant academic research and scientific papers
Study on the ArI-catalyzed intramolecularoxy-cyclization of 2-alkenylbenzamides to benzoiminolactones
Deng, Xiaojun,He, Wei,Huang, Xie,Ji, Nan,Liu, Huixia
, p. 3654 - 3658 (2020)
A new intramolecularoxy-cyclization of 2-alkenylbenzamides catalyzed by ArI has been developed. This protocol is highlighted by its metal-free catalytic system and extremely short reaction time, providing efficient and straightforward access to various benzoiminolactones in good to excellent yields. Interestingly, a regioselective transformation occurred when using two different reaction systems. Mechanistic studies suggested thatmCPBA acts as both oxidant and ligand at the IIIIcenter, and the Lewis acid BF3accelerated ligand exchange and reductive elimination in the catalytic process.
