35309-53-6

Basic information

• Product Name: CYCLO(-ASP-ASP)
• Synonyms: CYCLO(-ASP-ASP)
• CAS NO: 35309-53-6
• Molecular Formula: C₈H₁₀N₂O₆
• Molecular Weight: 230.17
• Mol File: 35309-53-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: CYCLO(-ASP-ASP)(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLO(-ASP-ASP)(35309-53-6)
• EPA Substance Registry System: CYCLO(-ASP-ASP)(35309-53-6)

Safety Data

• Hazardous Substances Data: 35309-53-6(Hazardous Substances Data)

Usage

General Description

CYCLO(-ASP-ASP), also known as cyclic aspartic acid, is a cyclic dipeptide formed by the cyclization of two aspartic acid residues. It is a naturally occurring compound and has been found in various protein and peptide sequences. This cyclic structure gives CYCLO(-ASP-ASP) greater stability and resistance to enzymatic degradation compared to linear peptides. It has been studied for its potential biological activities, including antimicrobial, antitumor, and immunomodulatory effects. Additionally, CYCLO(-ASP-ASP) has also been investigated for its potential use in drug delivery systems due to its stability and ability to penetrate cell membranes. Overall, CYCLO(-ASP-ASP) shows promise for various biomedical and pharmaceutical applications due to its unique structure and potential biological activities.

Upstream product

• 71989-14-5 Fmoc-(tBu)Asp-OH 
• 187671-16-5 Fmoc-Asp-OFm 
• 13798-75-9 N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 160940-47-6 diketopiperazine of L-aspartic acid dibenzyl ester 
• 56-84-8 L-Aspartic acid 

Downstream Products

• 160940-54-5 Bn-L-Phe-L-Phe-(diketo-L-Asp)-L-Phe-L-Phe-Bn 
• 160940-48-7 Bn-Gly-(diketo-L-Asp)-Gly-Bn 
• 160940-50-1 Bn-L-Val-(diketo-L-Asp)-L-Val-Bn 
• 160940-51-2 Bn-L-Tyr-(diketo-L-Asp)-L-Tyr-Bn 
• 160940-49-8 Bn-L-Ala-(diketo-L-Asp)-L-Ala-Bn 
• 178456-32-1 Bn-L,D-Phe-(diketo-L-Asp)-L,D-Phe-Bn 

Relevant articles and documents

Synthetic method of cyclic dipeptide containing aspartic acid and glutamic acid

The invention discloses a synthetic method of cyclic dipeptide containing aspartic acid and glutamic acid, which comprises the following steps: by taking Fmoc-Asp (OtBu)-OH or Fmoc-Glu (OtBu)-OH as a raw material, reacting with 9-fluorene methanol to obtain fluorene methyl ester of fully protected amino acid, and then removing side chain tert-butoxy to obtain protected amino acid Fmoc-Asp-OFm or Fmoc-Glu-OFm; 2-CTC Resin resin is used as a carrier to be bonded with Fmoc-Asp-OFm or Fmoc-Glu-OFm side chain gamma-carboxyl, solid-phase cyclization is carried out to synthesize full-protection cyclic dipeptide, and the cyclic dipeptide with aspartic acid or glutamic acid at the carbon end is obtained through cutting and cracking. According to the method, 9-fluorene methanol is introduced to protect carboxyl, the carboxyl can be smoothly removed in the solid-phase synthesis process of the dipeptide, the whole process is easy to operate, the solid-phase cyclization efficiency is high, the purity is high, and the method can be suitable for batch synthesis of cyclic dipeptide with aspartic acid or glutamic acid at the carbon end.

Template-assisted photodimerization of: N -unprotected uracil derivatives: Selective formation of the cis - Syn photodimer

A UV light-induced photodimerization of 5-[(imidazol-1-yl)methyl]uracil using glutamate- and aspartate-derived cyclic dipeptides (2,5-diketopiperazines-DKPs) as templates was investigated. Dual salt bridge formation between imidazole side chains and carboxylic acids resulted in the preorganization of the uracil monomers and the preferential formation of the cis-syn photodimer.

Macromolecular self-assembly of diketopiperazine tetrapeptides

Basic solutions of tetrapeptides derived from L-aspartic acid diketopiperazines are shown to form microcapsules when acidified to pH 2.4. An initial structure-activity study clearly demonstrates that a very delicate balance exists between the tetrapeptide