353248-34-7Relevant academic research and scientific papers
Biomimetic aerobic oxidation of amino alcohols to lactams
Babu, Beneesh P.,Endo, Yoshinori,Baeckvall, Jan-E.
, p. 11524 - 11527,4 (2012/12/11)
The right path: N-Protected amino alcohols undergo aerobic and biomimetic oxidation to the corresponding lactams in the presence of a ruthenium catalyst and a combination of electron-transfer mediators under air (see scheme). The reaction was used for the synthesis of five-, six-, and seven-, membered lactams and showed good tolerance to a number of N-protecting groups. Copyright
Synthesis of functionalized 1-azaspirocyclic cyclopentanones using bronsted acid or N-bromosuccinimide promoted ring expansions
Dake, Gregory R.,Fenster, Michael D. B.,Hurley, Paul B.,Patrick, Brian O.
, p. 5668 - 5675 (2007/10/03)
Azaspirocyclic ring systems are present in a variety of alkaloids. Functionalized 1-azaspirocyclopentanones (6, 7, 11, 12) can be efficiently constructed through semipinacol ring expansion reactions of 2-(1- hydroxycyclobutyl)-p-toluenesulfonylenamides (4
Construction of Azaspirocyclic Ketones through α-Hydroxyiminium Ion or α-Siloxy Epoxide Semipinacol Rearrangements
Fenster, Michael D. B.,Patrick, Brian O.,Dake, Gregory R.
, p. 2109 - 2112 (2007/10/03)
(matrix presented) method 1: R,R1=H, n=1 method 2: R=TMS, R1=OH, n=2 Semipinacol-type rearrangements to produce azaspirocyclic ketones are presented. The yields and stereoselectivities of these reactions range from 67-94% yield and 2
