3533-72-0

Basic information

• Product Name: 1,3-dihydro-2-benzothiophene 2-oxide
• Synonyms: 1,3-Dihydro-2-benzothiophene 2-oxide; benzo[c]thiophene, 1,3-dihydro-, 2-oxide
• CAS NO: 3533-72-0
• Molecular Formula: C₈H₈OS
• Molecular Weight: 152.2135
• Mol File: 3533-72-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 372.2°C at 760 mmHg
• Flash Point: 178.9°C
• Density: 1.33g/cm³
• Vapor Pressure: 2.09E-05mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: 1,3-dihydro-2-benzothiophene 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dihydro-2-benzothiophene 2-oxide(3533-72-0)
• EPA Substance Registry System: 1,3-dihydro-2-benzothiophene 2-oxide(3533-72-0)

Safety Data

• Hazardous Substances Data: 3533-72-0(Hazardous Substances Data)

Usage

Appearance

Colorless to pale yellow solid

Melting point

132-135°C

Boiling point

267-268°C

Uses

a. Intermediate in the synthesis of pharmaceuticals and agrochemicals
b. Building block for the preparation of other organic compounds

Biological and pharmacological activities

Potential in medicinal chemistry

Upstream product

• 608-23-1 3-chloro-o-xylene 
• 2471-92-3 1,3-Dihydrobenzothiophen 
• 612-12-4 o-Xylylene dichloride 
• 91-13-4 α,α'-dibromo-o-xylene 
• 95-47-6 o-xylene 
• 32970-96-0 cis-(cyclohex-4-ene-1,2-diyl)bis(methylene) bis(4-methylbenzenesulfonate) 
• 74626-69-0 cis-8-thiabicyclo<4.3.0>non-3-ene 

Downstream Products

• 2471-92-3 1,3-Dihydrobenzothiophen 
• 1194-57-6 2-thiophthalide 
• 270-82-6 benzo[c]thiophene 
• 13129-12-9 2-phenyl-(3at,9at)-3a,4,9,9a-tetrahydro-4r,9c-episulfano-benzo[f]isoindole-1,3-dione 
• 13129-13-0 2-phenyl-(3ac,9ac)-3a,4,9,9a-tetrahydro-4r,9c-episulfano-benzo[f]isoindole-1,3-dione 

Relevant articles and documents

Asymmetric Sulfoxidation Catalyzed by a Vanadium-Containing Bromoperoxidase

A vanadium-containing bromoperoxidase (VBrPO) from the alga Corallina officinalis has been shown to catalyze the stereoselective oxidation of some aromatic bicyclic sulfides to the corresponding (S)-sulfoxides in high (up to 91%) ee. Hydrogen peroxide was found to have a large effect on the catalyzed reaction, most likely due to an inhibition of VBrPO. High optical and chemical yields were found to be favored by a continuous slow addition of hydrogen peroxide to keep a low excess. The reaction gives no overoxidation to sulfone, and its stereochemistry is the opposite as compared to that previously found with the heme-containing chloroperoxidase (CPO) from Caldariomyces fumago.

Semiconductor material and preparation methods and applications thereof

The invention discloses a semiconductor material and preparation methods and applications thereof. A molecular structure general formula of the material is one of the formulas shown in the description. The semiconductor material provided by the invention

A green and sustainable method for the oxidation of 1,3-dihydrobenzo[c] thiophenes to sulfones using metalloporphyrin complexes

Two efficient methods are reported for the oxidation of 1,3-dihydrobenzo[c]thiophenes to sulfones in good to high yields using H 2O2 in the presence of catalytic amounts of porphyrin-based catalysts in ethanol or acetonitrile as solvents at room temperature. The presence of electron-donating or electron-withdrawing groups, in the benzene ring of 1,3-dihydrobenzo[c]thiophene, is well tolerated.