353302-39-3

Basic information

• Product Name: (4R,5S)-6-oxo-4-phenyl-5-(trimethyl-silanyl)-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester
• Synonyms: (4R,5S)-6-oxo-4-phenyl-5-(trimethyl-silanyl)-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester
• CAS NO: 353302-39-3
• Molecular Weight: 318.445
• Mol File: 353302-39-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5S)-6-oxo-4-phenyl-5-(trimethyl-silanyl)-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-6-oxo-4-phenyl-5-(trimethyl-silanyl)-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester(353302-39-3)
• EPA Substance Registry System: (4R,5S)-6-oxo-4-phenyl-5-(trimethyl-silanyl)-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester(353302-39-3)

Safety Data

• Hazardous Substances Data: 353302-39-3(Hazardous Substances Data)

Upstream product

• 4071-85-6 trimetylsilylketene 
• 17451-20-6 (E)-ethyl-2-oxo-4-phenylbut-3-enoate 
• 1026530-72-2 2-trimethylsilyl-ethoxyacetylene 

Downstream Products

• 353302-45-1 (2S,4R,5S)-6-oxo-4-phenyl-5-(trimethyl-silanyl)-tetrahydro-pyran-2-carboxylic acid ethyl ester 

Relevant articles and documents

C2-Symmetric Cu(II) Complexes as Chiral Lewis Acids. Catalytic, Enantioselective Cycloadditions of Silyl Ketenes

(matrix presented) C2-Symmetric bis(oxazoline)-Cu(II) complexes (4a-g) catalyze the enantioselective [2 + 2] cycloaddition between (silyl)ketenes and chelating carbonyl substrates. A range of substituted β-lactones can be produced in excellent yields and selectivities. It was also found that (trimethylsilyl)-ketene (1) may also undergo a highly selective hetero Diels-Alder reaction with β,γ-unsaturated α-keto esters.