35331-82-9Relevant articles and documents
Novel thiopyrano[3,2-b] and cycloalkeno[1,2-b]indole derivatives with high inhibitory properties in LTB4 production
Kuehm-Caubere, Catherine,Caubere, Paul,Jamart-Gregoire, Brigitte,Pfeiffer, Bruno,Guardiola-Lemaitre, Beatrice,Manechez, Dominique,Renard, Pierre
, p. 51 - 61 (1999)
Series of thiopyrano[3,2-b] and cycloalkeno[1,2-b]indoles were synthesized and evaluated in order to determine the necessary structural requirements for high leukotrienes biosynthesis inhibition. In vitro experiments showed that compounds 11b and 12b belonging to the second series were the most active and selective compounds on LTB4 production. Further in vivo investigations have shown additional very significant activity in the acute phorbol ester induced mouse ear swelling which is predictive of potential antipsoriatic properties.
Aggregative activation and heterocyclic chemistry I complex bases promoted arynic cyclisation of imines or enaminoketones; regiochemical synthesis of indoles
Caubere, Catherine,Caubere, Paul,Ianelli, Sandra,Nardelli, Mario,Jamart-Gregoire, Brigitte
, p. 11903 - 11920 (2007/10/02)
The complex base NaNH2-t-BuONa allowed expeditious syntheses of indoles by arynic cyclisation of imines or enaminoketones prepared from halogeno anilines and carbonyl derivatives. Unstable imines may be used without purification, complex bases being unsensitive to impurities. It is showed that this kind of reaction may be applied to mixture of substrates suitably halogenated on the benzene ring. Formation of three components aggregates is proposed to explain a number of observations.
